Evidence map›Paper›PMID 27447172›Full record

Observational studyVirchows Archiv : an international journal of pathology2016

Molecularly determined total tumour load in lymph nodes of stage I-II colon cancer patients correlates with high-risk factors. A multicentre prospective study.

Iban Aldecoa, Begoña Atares, Jordi Tarragona, Laia Bernet, Jose Domingo Sardon, Teresa Pereda, Carlos Villar, M Carmen Mendez, Elvira Gonzalez-Obeso, Kepa Elorriaga and 7 more

Open access · hybridAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Virchows Archiv : an international journal of pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Observational
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  14. Update of the recommendations for the determination of biomarkers in colorectal carcinoma: National Consensus of the Spanish Society of Medical Oncology and the Spanish Society of Pathology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Article
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  19. Factors associated with short recurrence-free survival in completely resected colon cancer.Journal of community hospital internal medicine perspectives · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 13 institutions in 1 country.

Iban AldecoaPathology Department, Centre de Diagnòstic Biomèdic (CDB), Hospital Clínic, University of Barcelona, Escala 3, Planta 5. Villarroel 170, Barcelona, 08036, Spain.
Begoña AtaresPathology Department, Alava University Hospital, Vitoria-Gasteiz, Spain.
Jordi TarragonaPathology Department, Hospital Arnau de Vilanova, Lleida, Spain.
Laia BernetPathology Department, Hospital L. Alcanyis, Xativa, Spain.
Jose Domingo SardonSurgery Department, Alava University Hospital, Txagorritxu, Spain.
Teresa PeredaPathology Department, Hospital Costa del Sol, Marbella, Spain.
Carlos VillarPathology Department, Hospital Reina Sofia, Cordoba, Spain.
M Carmen MendezPathology Department, Hospital Severo Ochoa, Leganes, Madrid, Spain.
Elvira Gonzalez-ObesoPathology Department, Hospital Severo Ochoa, Leganes, Madrid, Spain.
Kepa ElorriagaPathology Department, Hospital Onkologikoa, San Sebastian, Spain.
Guadalupe Lopez AlonsoPathology Department, Hospital 12 Octubre, Madrid, Spain.
Javier ZamoraBiostatistic Unit, Hospital Ramon y Cajal, Madrid, Spain.
Nuria PlanellGastroenterology Department and Bioinformatics Unit, CIBERehd, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Jose PalaciosPathology Department, Hospital Ramon y Cajal, Madrid, Spain.
Antoni CastellsGastroenterology Department, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain.
Xavier Matias-GuiuPathology Department, Hospital Arnau de Vilanova, Lleida, Spain.
Miriam CuatrecasasPathology Department, Centre de Diagnòstic Biomèdic (CDB), Hospital Clínic, University of Barcelona, Escala 3, Planta 5. Villarroel 170, Barcelona, 08036, Spain. mcuatrec@clinic.ub.es.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESHospital Arnau de Vilanova · ESHospital Universitario Ramón y Cajal · ESHospital Universitario Severo Ochoa · ESConsorci Institut D'Investigacions Biomediques August Pi I Sunyer · ESHospital Costa del Sol · ESHospital Lluis Alcanyis · ESHospital Txagorritxu · ESHospital Universitario Araba · ESHospital Universitario Reina Sofía · ESOnkologikoa · ESResearch Institute Hospital 12 de Octubre · ESUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stage I-II (pN0) colorectal cancer patients are surgically treated although up to 25 % will eventually die from disease recurrence. Lymph node (LN) status is an independent prognostic factor in colorectal cancer (CRC), and molecular tumour detection in LN of early-stage CRC patients is associated with an increased risk of disease recurrence and poor survival. This prospective multicentre study aimed to determine the relationship between LN molecular tumour burden and conventional high-risk factors in stage I-II colon cancer patients. A total of 1940 LN from 149 pathologically assessed pN0 colon cancer patients were analysed for the amount of tumour cytokeratin 19 (CK19) messenger RNA (mRNA) with the quantitative reverse transcription loop-mediated isothermal amplification molecular assay One-Step Nucleic Acid Amplification. Patient's total tumour load (TTL) resulted from the sum of all CK19 mRNA tumour copies/μL of each positive LN from the colectomy specimen. A median of 15 LN were procured per case (IQR 12;20). Molecular positivity correlated with high-grade (p < 0.01), mucinous/signet ring type (p = 0.017), male gender (p = 0.02), number of collected LN (p = 0.012) and total LN weight per case (p < 0.01). The TTL was related to pT stage (p = 0.01) and tumour size (p < 0.01) in low-grade tumours. Multivariate logistic regression showed independent correlation of molecular positivity with gender, tumour grade and number of fresh LN [AUC = 0.71 (95 % CI = 0.62-0.79)]. Our results show that lymph node CK19 mRNA detection correlates with classical high-risk factors in stage I-II colon cancer patients. Total tumour load is a quantitative and objective measure that may help to better stage early colon cancer patients.

Indexed as

AgedColonic NeoplasmsFemaleHumansLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingProspective StudiesRisk FactorsTumor BurdenColorectal neoplasmsCytokeratin 19Lymph nodesMolecular pathologyNeoplasm staging

Identifiers

PMID27447172
PMCPMC5033997
OpenAlexW2500290340

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.