ArticleThe Journal of comparative neurology2019
Rod-cone crossover connectome of mammalian bipolar cells.
Article in The Journal of comparative neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina.bioRxiv : the preprint server for biology · 2026Article
- Comparing a head-mounted virtual reality perimeter and the Humphrey Field Analyzer for visual field testing in healthy and glaucoma patients.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2024Article
- Spatial Cluster Patterns of Retinal Sensitivity Loss in Intermediate Age-Related Macular Degeneration Features.Translational vision science & technology · 2023Article
- Modulation of narrow-field amacrine cells on light-evoked spike responses and receptive fields of retinal ganglion cells.Vision research · 2023Article
- Distinctive synaptic structural motifs link excitatory retinal interneurons to diverse postsynaptic partner types.Cell reports · 2023Article
- Special nuclear layer contacts between starburst amacrine cells in the mouse retina.Frontiers in ophthalmology · 2023Article
- High sampling resolution optical coherence tomography reveals potential concurrent reductions in ganglion cell-inner plexiform and inner nuclear layer thickness but not in outer retinal thickness in glaucoma.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2023Article
- Retinal Pathoconnectomics: A Window into Neurodegeneration.Advances in experimental medicine and biology · 2023Article
- Dopamine D1 and D4 receptors contribute to light adaptation in ON-sustained retinal ganglion cells.Journal of neurophysiology · 2021Article
- A pathoconnectome of early neurodegeneration: Network changes in retinal degeneration.Experimental eye research · 2020Article
- Network Architecture of Gap Junctional Coupling among Parallel Processing Channels in the Mammalian Retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision.eLife · 2020Article
- Glycinergic and GABAergic interneurons shift the location and differentially alter the size of ganglion cell receptive field centers in the mammalian retina.Vision research · 2020Article
- Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina.Physiological reviews · 2019Review
- Design principles of electrical synaptic plasticity.Neuroscience letters · 2019Review
- Synaptic inputs from identified bipolar and amacrine cells to a sparsely branched ganglion cell in rabbit retina.Visual neuroscience · 2019Article
- A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retina.Physiological reports · 2018Article
- Heterocellular Coupling Between Amacrine Cells and Ganglion Cells.Frontiers in neural circuits · 2018Article
- Connectomics of synaptic microcircuits: lessons from the outer retina.The Journal of physiology · 2017Review
- Graffinity: Visualizing Connectivity in Large Graphs.Computer graphics forum : journal of the European Association for Computer Graphics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
The basis of cross-suppression between rod and cone channels has long been an enigma. Using rabbit retinal connectome RC1, we show that all cone bipolar cell (BC) classes inhibit rod BCs via amacrine cell (AC) motifs (C1-6); that all cone BC classes are themselves inhibited by AC motifs (R1-5, R25) driven by rod BCs. A sparse symmetric AC motif (CR) is presynaptic and postsynaptic to both rod and cone BCs. ON cone BCs of all classes drive inhibition of rod BCs via motif C1 wide-field GABAergic ACs (γACs) and motif C2 narrow field glycinergic ON ACs (GACs). Each rod BC receives ≈10 crossover AC synapses and each ON cone BC can target ≈10 or more rod BCs via separate AC processes. OFF cone BCs mediate monosynaptic inhibition of rod BCs via motif C3 driven by OFF γACs and GACs and disynaptic inhibition via motifs C4 and C5 driven by OFF wide-field γACs and narrow-field GACs, respectively. Motifs C4 and C5 form halos of 60-100 inhibitory synapses on proximal dendrites of AI γACs. Rod BCs inhibit surrounding arrays of cone BCs through AII GAC networks that access ON and OFF cone BC patches via motifs R1, R2, R4, R5 and a unique ON AC motif R3 that collects rod BC inputs and targets ON cone BCs. Crossover synapses for motifs C1, C4, C5, and R3 are 3-4× larger than typical feedback synapses, which may be a signature for synaptic winner-take-all switches. J. Comp. Neurol. 527:87-116, 2019. © 2016 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.