Evidence map›Paper›PMID 27446988›Full record

ArticleJournal of nature and science2015

A human anti-polysialic acid antibody as a potential treatment to improve function in multiple sclerosis patients.

Jens O Watzlawik, Meghan M Painter, Bharath Wootla, Moses Rodriguez

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of nature and science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jens O WatzlawikDepartment of Neurology, Clinic College of Medicine, Rochester, Minnesota, USA.
Meghan M PainterMayo Graduate School, Clinic College of Medicine, Rochester, Minnesota, USA.
Bharath WootlaDepartment of Neurology, Clinic College of Medicine, Rochester, Minnesota, USA.
Moses RodriguezDepartment of Neurology, Clinic College of Medicine, Rochester, Minnesota, USA.
Mayo Clinic · US

Funding

Transgenic expression of Theiler's Virus encoded regionsP01NS038468 · NINDS · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI RODRIGUEZ, MOSES · 2000 to 2004
$5.0M
T cell Function in Murine Model of Multiple SclerosisR01NS032129 · NINDS · MAYO CLINIC ROCHESTER · PI RODRIGUEZ, MOSES · 1994 to 2010
$2.7M
IMMUNE PROMOTION OF REMYELINATIONR01NS024180 · NINDS · MAYO CLINIC ROCHESTER · PI RODRIGUEZ, MOSES · 1987 to 2008
$2.7M
NINDS NIH HHS P01 NS038468NINDS NIH HHS R01 NS024180NINDS NIH HHS R01 NS032129
6 · The paper itself

Abstract

We previously identified a human monoclonal antibody, termed HIgM12 that stimulates spontaneous locomotor activity in a chronically demyelinating mouse model of multiple sclerosis. When tested as a molecular substrate, HIgM12 stimulated neurite outgrowth

Indexed as

antibodymotor functionmultiple sclerosispolysialic acid

Identifiers

PMID27446988
PMCPMC4951103
OpenAlexW1933397944

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.