ArticleNeurophotonics2016
Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy.
Article in Neurophotonics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04347590 (Impact of Continuous Glucose Monitoring on Cerebral Oxygenation in Preterm Infants), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Continuous Glucose Monitoring on Cerebral Oxygenation in Preterm Infants (the Babyglucolight Trial)
Who cites it
23 citing papers in PubMed.
- Disrupted functional connectivity during stroke recovery revealed via bedside optical neuroimaging.Neurophotonics · 2026Article
- Electroencephalography and optical neuromonitoring predict short-term outcomes in neonates undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy.Scientific reports · 2025Article
- Article
- Multimodal fNIRS-EEG sensor fusion: Review of data-driven methods and perspective for naturalistic brain imaging.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Developing customized NIRS-EEG for infant sleep research: methodological considerations.Neurophotonics · 2023Article
- The effect of burst suppression on cerebral blood flow and autoregulation: a scoping review of the human and animal literature.Frontiers in physiology · 2023Article
- Ultrafast and Ultrahigh-Resolution Diffuse Optical Tomography for Brain Imaging with Sensitivity Equation based Noniterative Sparse Optical Reconstruction (SENSOR).Journal of quantitative spectroscopy & radiative transfer · 2021Article
- A retrospective study of electroencephalography burst suppression in children undergoing general anesthesia.Pediatric investigation · 2021Article
- Wearable, Integrated EEG-fNIRS Technologies: A Review.Sensors (Basel, Switzerland) · 2021Review
- Construction and validation of a database of head models for functional imaging of the neonatal brain.Human brain mapping · 2021Article
- Hemodynamic changes associated with common EEG patterns in critically ill patients: Pilot results from continuous EEG-fNIRS study.NeuroImage. Clinical · 2021Article
- Design and validation of a mechanically flexible and ultra-lightweight high-density diffuse optical tomography system for functional neuroimaging of newborns.Neurophotonics · 2021Article
- Neurovascular coupling in the developing neonatal brain at rest.Human brain mapping · 2020Article
- High-density diffuse optical tomography for imaging human brain function.The Review of scientific instruments · 2019Article
- Neonatal brain injury and aberrant connectivity.NeuroImage · 2019Review
- Electroencephalographic features of discontinuous activity in anesthetized infants and children.PloS one · 2019Article
- Splanchnic NIRS monitoring in neonatal care: rationale, current applications and future perspectives.Journal of perinatology : official journal of the California Perinatal Association · 2018Review
- Mild Hypothermia Therapy for Moderate or Severe Hypoxicischemic Encephalopathy in Neonates.Iranian journal of public health · 2018Article
- Diffuse optical tomography to investigate the newborn brain.Pediatric research · 2017Review
- Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data.Neurophotonics · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Burst suppression (BS) is an electroencephalographic state associated with a profound inactivation of the brain. BS and pathological discontinuous electroencephalography (EEG) are often observed in term-age infants with neurological injury and can be indicative of a poor outcome and lifelong disability. Little is known about the neurophysiological mechanisms of BS or how the condition relates to the functional state of the neonatal brain. We used simultaneous EEG and diffuse optical tomography (DOT) to investigate whether bursts of EEG activity in infants with hypoxic ischemic encephalopathy are associated with an observable cerebral hemodynamic response. We were able to identify significant changes in concentration of both oxy and deoxyhemoglobin that are temporally correlated with EEG bursts and present a relatively consistent morphology across six infants. Furthermore, DOT reveals patient-specific spatial distributions of this hemodynamic response that may be indicative of a complex pattern of cortical activation underlying discontinuous EEG activity that is not readily apparent in scalp EEG.
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Registered trials
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