Evidence map›Paper›PMID 27446919›Full record

ReviewFrontiers in cell and developmental biology2016

Assembly and Turnover of Caveolae: What Do We Really Know?

Bing Han, Courtney A Copeland, Ajit Tiwari, Anne K Kenworthy

Abstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Caveolin and NOS in the Development of Muscular Dystrophy.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Review
  5. Article
  6. Generation of nanoscopic membrane curvature for membrane trafficking.Nature reviews. Molecular cell biology · 2023
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Caveolae as Potential Hijackable Gates in Cell Communication.Frontiers in cell and developmental biology · 2020
    Review
  13. Energy and Dynamics of Caveolae Trafficking.Frontiers in cell and developmental biology · 2020
    Review
  14. Review
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bing HanDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine Nashville, TN, USA.
Courtney A CopelandDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine Nashville, TN, USA.
Ajit TiwariDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine Nashville, TN, USA.
Anne K KenworthyDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of MedicineNashville, TN, USA; Department of Cell and Developmental Biology, Vanderbilt University School of MedicineNashville, TN, USA; Epithelial Biology Program, Vanderbilt University School of MedicineNashville, TN, USA; Chemical and Physical Biology Program, Vanderbilt UniversityNashville, TN, USA.

Funding

Vanderbilt/Meharry Initiative for Minority Student DvptR25GM062459 · NIGMS · VANDERBILT UNIVERSITY · PI VELEZ EDWARDS, DIGNA R · 2002 to 2020
$10.4M
Caveolar Defects Underlie the Genetic Origins of PAHR01HL111259 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KENWORTHY, ANNE K, LOYD, JAMES E · 2012 to 2016
$3.5M
NHLBI NIH HHS R01 HL111259NIGMS NIH HHS R25 GM062459
6 · The paper itself

Abstract

In addition to containing highly dynamic nanoscale domains, the plasma membranes of many cell types are decorated with caveolae, flask-shaped domains enriched in the structural protein caveolin-1 (Cav1). The importance of caveolae in numerous cellular functions and processes has become well-recognized, and recent years have seen dramatic advances in our understanding of how caveolae assemble and the mechanisms control the turnover of Cav1. At the same time, work from our lab and others have revealed that commonly utilized strategies such as overexpression and tagging of Cav1 have unexpectedly complex consequences on the trafficking and fate of Cav1. Here, we discuss the implications of these findings for current models of caveolae biogenesis and Cav1 turnover. In addition, we discuss how disease-associated mutants of Cav1 impact caveolae assembly and outline open questions in this still-emerging area.

Indexed as

breast cancercaveolaecaveolin-1congenital generalized lipodystrophydegradationGFPpulmonary arterial hypertensiontrafficking

Identifiers

PMID27446919
PMCPMC4921483

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.