ArticleMaxillofacial plastic and reconstructive surgery2016
Bone regenerative effect of recombinant human bone morphogenetic protein-2 after cyst enucleation.
Article in Maxillofacial plastic and reconstructive surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Optimizing rhBMP-2 Therapy for Bone Regeneration: From Safety Concerns to Biomaterial-Guided Delivery Systems.International journal of molecular sciences · 2025Review
- Long-Term Changes in Adipose Tissue in the Newly Formed Bone Induced by Recombinant Human BMP-2 In Vivo.Biomimetics (Basel, Switzerland) · 2023Article
- Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2.International journal of molecular sciences · 2021Article
- Enhanced Bone Regeneration in Variable-Type Biphasic Ceramic Phosphate Scaffolds Using rhBMP-2.International journal of molecular sciences · 2021Article
- Bone regeneration in ceramic scaffolds with variable concentrations of PDRN and rhBMP-2.Scientific reports · 2021Article
- Effect of rhBMP-2 applied with a 3D-printed titanium implant on new bone formation in rabbit calvarium.Journal of applied oral science : revista FOB · 2021Article
- Risk factors for postoperative infection of odontogenic cysts associated with mandibular third molar.Maxillofacial plastic and reconstructive surgery · 2020Article
- 3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures.International journal of molecular sciences · 2020Article
- Regenerative effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) after sequestrectomy of medication-related osteonecrosis of the jaw (MRONJ).Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2020Article
- Evaluation of the Bone Regeneration Effect of Recombinant Human Bone Morphogenic Protein-2 on Subperiosteal Bone Graft in the Rat Calvarial Model.Materials (Basel, Switzerland) · 2019Article
- Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives.Biomaterials · 2018Review
- Evaluation of BMP-2 Enhances the Osteoblast Differentiation of Human Amnion Mesenchymal Stem Cells Seeded on Nano-Hydroxyapatite/Collagen/Poly(l-Lactide).International journal of molecular sciences · 2018Article
- Evaluation of bone healing using rhBMP-2 soaked hydroxyapatite in ridge augmentation: a prospective observational study.Maxillofacial plastic and reconstructive surgery · 2017Article
- Effects ofBioscience reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study is to quantitatively evaluate the effect of rhBMP-2 for repair of bone defects after cyst enucleation using the osteogenesis index (OI).
methodsUnder general anesthesia, 10 patients (12 lesions) underwent oral or maxillofacial surgery for cyst enucleation. Postoperatively, 12 lesions were divided into two groups: group A (six lesions) was treated with absorbable collagen sponge (ACS) in combination with rhBMP-2, and group B (six lesions) was treated with ACS alone. After 3 months, cone-beam computed tomographic scans were obtained to measure changes in the volume of the lesions. We then calculated the OI of each group at two different Hounsfield units to determine any statistically significant difference between these two groups (Mann-Whitney
resultsAs tested at the level of new bone, the mean OI was 72.37 % in group A and 55.08 % in group B -a statistically significant difference (
conclusionsThe application of rhBMP-2 after maxillofacial cyst enucleation accelerated new bone formation in the bone defects. Thus, the use of rhBMP-2 in combination with ACS may be considered an alternative to conventional bone grafting in some patients with postoperative bone defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.