ArticleFrontiers in cellular and infection microbiology2016
In vitro Effects of Lemongrass Extract on Candida albicans Biofilms, Human Cells Viability, and Denture Surface.
Article in Frontiers in cellular and infection microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of thymus vulgaris essential oil as an antifungal agent on the flexural strength, surface roughness, and color stability of polymethyl methacrylate acrylic resin.Scientific reports · 2026Article
- Dual-Loaded Galangal Extract and Lemongrass Oil Biobased Self-Emulsifying System for Denture-Cleansing Applications.ACS omega · 2026Article
- Multitarget Anti-Scientifica · 2025Article
- Died or Not Dyed: Assessment of Viability and Vitality Dyes on Planktonic Cells and Biofilms fromJournal of fungi (Basel, Switzerland) · 2024Article
- Effectiveness of Lemon Verbena (Clinical, cosmetic and investigational dentistry · 2024Review
- Biological Activity of Biosynthesized Silver Nanoaggregates Prepared from the Aqueous Extract ofNanomaterials (Basel, Switzerland) · 2023Article
- The Cytotoxic and Inhibitory Effects of Plant Derivatives onMolecules (Basel, Switzerland) · 2022Article
- Targeting Virulence Factors ofFoods (Basel, Switzerland) · 2022Review
- Ceragenin CSA-44 as a Means to Control the Formation of the Biofilm on the Surface of Tooth and Composite Fillings.Pathogens (Basel, Switzerland) · 2022Article
- Article
- Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities.Antioxidants (Basel, Switzerland) · 2021Review
- Antibiofilm Potential of Medicinal Plants againstAntibiotics (Basel, Switzerland) · 2021Review
- Guanidine derivative inhibits C. albicans biofilm growth on denture liner without promote loss of materials' resistance.Bioactive materials · 2020Article
- Lemon Grass Essential Oil Does not Modulate Cancer Cells Multidrug Resistance by Citral-Its Dominant and Strongly Antimicrobial Compound.Foods (Basel, Switzerland) · 2020Article
- Antimicrobial Activity of Lemongrass Essential Oil (Frontiers in cellular and infection microbiology · 2020Article
- Effect ofEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Anti-biofilm Action ofFrontiers in microbiology · 2019Article
- Effects ofJournal of clinical and experimental dentistry · 2018Article
- Effect of the Ethyl Acetate Fraction ofFrontiers in microbiology · 2017Article
- Antifungal effects of tulsi, garlic, cinnamon and lemongrass in powder and oil form onJournal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to investigate whether immersion of a denture surface in lemongrass extract (LGE) has effects on C. albicans biofilms, human cell viability and denture surface. Minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) were performed for LGE against C. albicans. For biofilm analysis, discs were fabricated using a denture acrylic resin with surface roughness standardization. C. albicans biofilms were developed on saliva-coated discs, and the effects of LGE at MIC, 5XMIC, and 10XMIC were investigated during biofilm formation and after biofilm maturation. Biofilms were investigated for cell counting, metabolic activity, and microscopic analysis. The cytotoxicity of different concentrations of LGE to peripheral blood mononuclear cells (PBMC) was analyzed using MTT. The effects of LGE on acrylic resin were verified by measuring changes in roughness, color and flexural strength after 28 days of immersion. Data were analyzed by ANOVA, followed by a Tukey test at a 5% significance level. The minimal concentration of LGE required to inhibit C. albicans growth was 0.625 mg/mL, while MFC was 2.5 mg/mL. The presence of LGE during biofilm development resulted in a reduction of cell counting (p < 0.05), which made the MIC sufficient to reduce approximately 90% of cells (p < 0.0001). The exposure of LGE after biofilm maturation also had a significant antifungal effect at all concentrations (p < 0.05). When compared to the control group, the exposure of PBMC to LGE at MIC resulted in similar viability (p > 0.05). There were no verified differences in color perception, roughness, or flexural strength after immersion in LGE at MIC compared to the control (p > 0.05). It could be concluded that immersion of the denture surface in LGE was effective in reducing C. albicans biofilms with no deleterious effects on acrylic properties at MIC. MIC was also an effective and safe concentration for use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.