ArticleBiomedical optics express2016
Velocity measurements in whole blood using acoustic resolution photoacoustic Doppler.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Vector-flow imaging of slowly movingPhotoacoustics · 2024Article
- Photoacoustic vector tomography for deep haemodynamic imaging.Nature biomedical engineering · 2024Article
- Functional photoacoustic microscopy of hemodynamics: a review.Biomedical engineering letters · 2022Review
- Photoacoustic imaging of 3D-printed vascular networks.Biofabrication · 2022Article
- Enhanced visibility through microbubble-induced photoacoustic fluctuation imaging.JASA express letters · 2022Article
- Optoacoustic Imaging in Inflammation.Biomedicines · 2021Review
- Photoacoustic Tomography Opening New Paradigms in Biomedical Imaging.Advances in experimental medicine and biology · 2021Article
- Single-shot photoacoustic microscopy of hemoglobin concentration, oxygen saturation, and blood flow in sub-microseconds.Photoacoustics · 2020Article
- Longitudinal Photoacoustic Imaging of the Pharmacodynamic Effect of Vascular Targeted Therapy on Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Photoacoustic imaging as a tool to probe the tumour microenvironment.Disease models & mechanisms · 2019Review
- Monitoring neovascularization and integration of decellularized human scaffolds using photoacoustic imaging.Photoacoustics · 2019Article
- Photoacoustic microscopy: principles and biomedical applications.Biomedical engineering letters · 2018Review
- Advanced optoacoustic methods for multiscale imaging of in vivo dynamics.Chemical Society reviews · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acoustic resolution photoacoustic Doppler velocimetry promises to overcome the spatial resolution and depth penetration limitations of current blood flow measuring methods. Despite successful implementation using blood-mimicking fluids, measurements in blood have proved challenging, thus preventing in vivo application. A common explanation for this difficulty is that whole blood is insufficiently heterogeneous relative to detector frequencies of tens of MHz compatible with deep tissue photoacoustic measurements. Through rigorous experimental measurements we provide new insight that refutes this assertion. We show for the first time that, by careful choice of the detector frequency and field-of-view, and by employing novel signal processing methods, it is possible to make velocity measurements in whole blood using transducers with frequencies in the tens of MHz range. These findings have important implications for the prospects of making deep tissue measurements of blood flow relevant to the study of microcirculatory abnormalities associated with cancer, diabetes, atherosclerosis and other conditions.
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Registered trials
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