Evidence map›Paper›PMID 27446700›Full record

ArticleBiomedical optics express2016

Characterizing relationship between optical microangiography signals and capillary flow using microfluidic channels.

Woo June Choi, Wan Qin, Chieh-Li Chen, Jingang Wang, Qinqin Zhang, Xiaoqi Yang, Bruce Z Gao, Ruikang K Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 61 citations in OpenAlex.

  1. Endothelial expression of human soluble epoxide hydrolase worsens acute microvascular and tissue injury after stroke in female mice with early-stage diabetes mellitus.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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  14. Artifacts and artifact removal in optical coherence tomographic angiography.Quantitative imaging in medicine and surgery · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Woo June ChoiDepartment of Bioengineering, University of Washington, 3720 15th NE, Seattle, WA 98195, USA; These authors contributed equally to this work.
Wan QinDepartment of Bioengineering, University of Washington, 3720 15th NE, Seattle, WA 98195, USA; These authors contributed equally to this work.
Chieh-Li ChenDepartment of Bioengineering, University of Washington, 3720 15th NE, Seattle, WA 98195, USA.
Jingang WangDepartment of Bioengineering, University of Washington, 3720 15th NE, Seattle, WA 98195, USA.
Qinqin ZhangDepartment of Bioengineering, University of Washington, 3720 15th NE, Seattle, WA 98195, USA.
Xiaoqi YangDepartment of Bioengineering and COMSET, Clemson University, Clemson, SC 29634, USA.
Bruce Z GaoDepartment of Bioengineering and COMSET, Clemson University, Clemson, SC 29634, USA.
Ruikang K WangDepartment of Bioengineering, University of Washington, 3720 15th NE, Seattle, WA 98195, USA.
University of Washington · USClemson University · US

Funding

OPTICAL MICROANGIOGRAHY OF CEREBROVASCULAR PERFUSIONR01HL093140 · NHLBI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2008 to 2017
$4.2M
NON-INVASIVE REAL-TIME LABEL-FREE 3D IMAGING OF RETINAL MICROCIRCULATIONR01EY024158 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2014 to 2017
$1.7M
NEI NIH HHS R01 EY024158NHLBI NIH HHS R01 HL093140
6 · The paper itself

Abstract

Optical microangiography (OMAG) is a powerful optical angio-graphic tool to visualize micro-vascular flow in vivo. Despite numerous demonstrations for the past several years of the qualitative relationship between OMAG and flow, no convincing quantitative relationship has been proven. In this paper, we attempt to quantitatively correlate the OMAG signal with flow. Specifically, we develop a simplified analytical model of the complex OMAG, suggesting that the OMAG signal is a product of the number of particles in an imaging voxel and the decorrelation of OCT (optical coherence tomography) signal, determined by flow velocity, inter-frame time interval, and wavelength of the light source. Numerical simulation with the proposed model reveals that if the OCT amplitudes are correlated, the OMAG signal is related to a total number of particles across the imaging voxel cross-section per unit time (flux); otherwise it would be saturated but its strength is proportional to the number of particles in the imaging voxel (concentration). The relationship is validated using microfluidic flow phantoms with various preset flow metrics. This work suggests OMAG is a promising quantitative tool for the assessment of vascular flow.

Indexed as

(170.2655) Functional monitoring and imaging(170.4500) Optical coherence tomography(220.4000) Microstructure fabrication

Identifiers

PMID27446700
PMCPMC4948624
OpenAlexW2473291230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.