ArticleBiomedical optics express2016
Super-resolved thickness maps of thin film phantoms and in vivo visualization of tear film lipid layer using OCT.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The Impact of Photopigment Bleaching on the Human Rod Photoreceptor Subretinal Space Measured Via Optical Coherence Tomography.Investigative ophthalmology & visual science · 2024Article
- Recent Progress on Optical Tomographic Technology for Measurements and Inspections of Film Structures.Micromachines · 2022Review
- Feasibility of Silicon Quantum Dots as a Biomarker for the Bioimaging of Tear Film.Nanomaterials (Basel, Switzerland) · 2022Article
- Quantification of intrinsic optical signals in the outer human retina using optical coherence tomography.Annals of the New York Academy of Sciences · 2022Article
- The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques.Frontiers in medicine · 2022Review
- Laser-induced corneal injury: validation of a computer model to predict thresholds.Biomedical optics express · 2021Article
- Advances in Imaging Technology of Anterior Segment of the Eye.Journal of ophthalmology · 2021Review
- The Association between Tear Film Thickness as Measured with OCT and Symptoms and Signs of Dry Eye Disease: A Pooled Analysis of 6 Clinical Trials.Journal of clinical medicine · 2020Article
- Spectroscopic Optical Coherence Tomography for Thin Layer and Foil Measurements.Sensors (Basel, Switzerland) · 2020Article
- Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease.Diagnostics (Basel, Switzerland) · 2020Review
- Real-time non-contact cellular imaging and angiography of human cornea and limbus with common-path full-field/SD OCT.Nature communications · 2020Article
- Light-induced changes of the subretinal space of the temporal retina observed via optical coherence tomography.Scientific reports · 2019Article
- Characterization of dry eye disease in a mouse model by optical coherence tomography and fluorescein staining.Biomedical optics express · 2019Article
- Automatic assessment of tear film and tear meniscus parameters in healthy subjects using ultrahigh-resolution optical coherence tomography.Biomedical optics express · 2019Article
- In vivo thickness measurement of the lipid layer and the overall tear film by interferometry.Optics letters · 2019Article
- CorneaNet: fast segmentation of cornea OCT scans of healthy and keratoconic eyes using deep learning.Biomedical optics express · 2019Article
- An imaging system integrating optical coherence tomography and interferometry for in vivo measurement of the thickness and dynamics of the tear film.Biomedical engineering online · 2018Article
- Ultrahigh-resolution OCT imaging of the human cornea.Biomedical optics express · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In optical coherence tomography (OCT), the axial resolution is directly linked to the coherence length of the employed light source. It is currently unclear if OCT allows measuring thicknesses below its axial resolution value. To investigate spectral-domain OCT imaging in the super-resolution regime, we derived a signal model and compared it with the experiment. Several island thin film samples of known refractive indices and thicknesses in the range 46 - 163 nm were fabricated and imaged. Reference thickness measurements were performed using a commercial atomic force microscope. In vivo measurements of the tear film were performed in 4 healthy subjects. Our results show that quantitative super-resolved thickness measurement can be performed using OCT. In addition, we report repeatable tear film lipid layer visualization. Our results provide a novel interpretation of the OCT axial resolution limit and open a perspective to deeper extraction of the information hidden in the coherence volume.
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