Evidence map›Paper›PMID 27446692›Full record

ArticleBiomedical optics express2016

Automated fine structure image analysis method for discrimination of diabetic retinopathy stage using conjunctival microvasculature images.

Maziyar M Khansari, William O'Neill, Richard Penn, Felix Chau, Norman P Blair, Mahnaz Shahidi

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Maziyar M KhansariDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, 60612, USA; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, 60607, USA.
William O'NeillDepartment of Bioengineering, University of Illinois at Chicago, Chicago, IL, 60607, USA.
Richard PennDepartment of Bioengineering, University of Illinois at Chicago, Chicago, IL, 60607, USA; Department of Neurosurgery, Rush University and Hospital, Chicago, Illinois 60612, USA.
Felix ChauDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Norman P BlairDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, 60612, USA.
Mahnaz ShahidiDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, 60612, USA; Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, 60607, USA.
University of Illinois Chicago · USRush University · US

Funding

Translational Core for Therapeutic and Diagnostic DevelopmentP30EY001792 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AAKALU, VINAY · 1985 to 2025
$14.8M
Ocular Biomarkers of Microvascular, Neural and Metabolic Function in DiabetesDP3DK104393 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SHAHIDI, MAHNAZ · 2014 to 2014
$1.5M
NEI NIH HHS P30 EY001792NIDDK NIH HHS DP3 DK104393
6 · The paper itself

Abstract

The conjunctiva is a densely vascularized mucus membrane covering the sclera of the eye with a unique advantage of accessibility for direct visualization and non-invasive imaging. The purpose of this study is to apply an automated quantitative method for discrimination of different stages of diabetic retinopathy (DR) using conjunctival microvasculature images. Fine structural analysis of conjunctival microvasculature images was performed by ordinary least square regression and Fisher linear discriminant analysis. Conjunctival images between groups of non-diabetic and diabetic subjects at different stages of DR were discriminated. The automated method's discriminate rates were higher than those determined by human observers. The method allowed sensitive and rapid discrimination by assessment of conjunctival microvasculature images and can be potentially useful for DR screening and monitoring.

Indexed as

(080.2720) Mathematical methods (general)(100.0100) Image processing(100.2960) Image analysis(170.1610) Clinical applications(170.4470) Ophthalmology

Identifiers

PMID27446692
PMCPMC4948616
OpenAlexW2438306604

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.