ArticleBiomedical optics express2016
Multiple pinhole collimator based X-ray luminescence computed tomography.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Automated Restarting Fast Proximal Gradient Descent Method for Single-View Cone-Beam X-ray Luminescence Computed Tomography Based on Depth Compensation.Bioengineering (Basel, Switzerland) · 2024Article
- Superfast Scan of Focused X-Ray Luminescence Computed Tomography Imaging.IEEE access : practical innovations, open solutions · 2023Article
- Contrast agents for x-ray luminescence computed tomography.Applied optics · 2021Article
- Focused x-ray luminescence imaging system for small animals based on a rotary gantry.Journal of biomedical optics · 2021Article
- High-speed X-ray-induced luminescence computed tomography.Journal of biophotonics · 2020Article
- High-resolution x-ray luminescence computed tomography.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- X-ray luminescence imaging for small animals.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- X-ray-induced shortwave infrared luminescence computed tomography.Optics letters · 2019Article
- Method for improving the spatial resolution of narrow x-ray beam-based x-ray luminescence computed tomography imaging.Journal of biomedical optics · 2019Article
- Tomographic Cherenkov-excited luminescence scanned imaging with multiple pinhole beams recovered via back-projection reconstruction.Optics letters · 2019Article
- Background luminescence in x-ray luminescence computed tomography (XLCT) imaging.Applied optics · 2019Article
- Focused x-ray luminescence computed tomography: experimental studies.Proceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Time domain X-ray luminescence computed tomography: numerical simulations.Biomedical optics express · 2019Article
- Regularized reconstruction based on joint LBiomedical optics express · 2019Article
- Gamma rays excited radioluminescence tomographic imaging.Biomedical engineering online · 2018Article
- X-ray luminescence computed tomography using a focused x-ray beam.Journal of biomedical optics · 2017Article
- Sensitivity evaluation and selective plane imaging geometry for x-ray-induced luminescence imaging.Medical physics · 2017Article
- Sensitivity study of x-ray luminescence computed tomography.Applied optics · 2017Article
- Collimated superfine x-ray beam based x-ray luminescence computed tomography.Journal of X-ray science and technology · 2017Article
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Authors and funding
4 authors.
Funding
Abstract
X-ray luminescence computed tomography (XLCT) is an emerging hybrid imaging modality, which is able to improve the spatial resolution of optical imaging to hundreds of micrometers for deep targets by using superfine X-ray pencil beams. However, due to the low X-ray photon utilization efficiency in a single pinhole collimator based XLCT, it takes a long time to acquire measurement data. Herein, we propose a multiple pinhole collimator based XLCT, in which multiple X-ray beams are generated to scan a sample at multiple positions simultaneously. Compared with the single pinhole based XLCT, the multiple X-ray beam scanning method requires much less measurement time. Numerical simulations and phantom experiments have been performed to demonstrate the feasibility of the multiple X-ray beam scanning method. In one numerical simulation, we used four X-ray beams to scan a cylindrical object with 6 deeply embedded targets. With measurements from 6 angular projections, all 6 targets have been reconstructed successfully. In the phantom experiment, we generated two X-ray pencil beams with a collimator manufactured in-house. Two capillary targets with 0.6 mm edge-to-edge distance embedded in a cylindrical phantom have been reconstructed successfully. With the two beam scanning, we reduced the data acquisition time by 50%. From the reconstructed XLCT images, we found that the Dice similarity of targets is 85.11% and the distance error between two targets is less than 3%. We have measured the radiation dose during XLCT scan and found that the radiation dose, 1.475 mSv, is in the range of a typical CT scan. We have measured the changes of the collimated X-ray beam size and intensity at different distances from the collimator. We have also studied the effects of beam size and intensity in the reconstruction of XLCT.
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