ArticleBiomedical optics express2016
Polarization properties of single layers in the posterior eyes of mice and rats investigated using high resolution polarization sensitive optical coherence tomography.
Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Histology correlated adaptive optics polarisation sensitive optical coherence tomography.Biomedical optics express · 2026Article
- Retinal OCT Parameters and Physiological Dynamics as an Effect of Anesthesia in C57BL/6J Mice.Investigative ophthalmology & visual science · 2026Article
- Blood flow analysis of retinal neovascularisations in a VLDLR mouse model using contrast-enhanced optical coherence tomography.Biomedical optics express · 2026Article
- Longitudinal investigation of spatial memory and retinal parameters in a 5xFAD model of Alzheimer's disease reveals differences dependent on genotype and sex.Biomedical optics express · 2026Article
- Comparative Investigation of the Retinal Phenotype of Three Mouse Models of Alzheimer's Disease With Optical Coherence Tomography.Investigative ophthalmology & visual science · 2025Article
- OCT Imaging in Murine Models of Alzheimer's Disease in a Systematic Review: Findings, Methodology and Future Perspectives.Biomedicines · 2024Review
- Synthesizing the degree of polarization uniformity from non-polarization-sensitive optical coherence tomography signals using a neural network.Biomedical optics express · 2023Article
- Degeneration of Melanin-Containing Structures Observed Longitudinally in the Eyes of SOD1-/- Mice Using Intensity, Polarization, and Spectroscopic OCT.Translational vision science & technology · 2022Article
- Pulsatile tissue deformation dynamics of the murine retina and choroid mapped by 4D optical coherence tomography.Biomedical optics express · 2022Article
- High-resolution, depth-resolved vascular leakage measurements using contrast-enhanced, correlation-gated optical coherence tomography in mice.Biomedical optics express · 2021Article
- Optical Coherence Tomography Findings in the Retinas of SOD1 Knockout Mice.Translational vision science & technology · 2020Article
- Retinal analysis of a mouse model of Alzheimer's disease with multicontrast optical coherence tomography.Neurophotonics · 2020Article
- Signal averaging improves signal-to-noise in OCT images: But which approach works best, and when?Biomedical optics express · 2019Article
- Scattering-Angle-Resolved Optical Coherence Tomography of a Hypoxic Mouse Retina Model.Journal of experimental neuroscience · 2019Article
- Supercontinuum source-based multi-contrast optical coherence tomography for rat retina imaging.Biomedical optics express · 2018Article
- White light polarization sensitive optical coherence tomography for sub-micron axial resolution and spectroscopic contrast in the murine retina.Biomedical optics express · 2018Article
- Multicontrast endomyocardial imaging by single-channel high-resolution cross-polarization optical coherence tomography.Journal of biophotonics · 2018Article
- Imaging retinal melanin: a review of current technologies.Journal of biological engineering · 2018Review
- Ocular fundus pulsations within the posterior rat eye: Chorioscleral motion and response to elevated intraocular pressure.Scientific reports · 2017Article
- Polarization sensitive optical coherence tomography - a review [Invited].Biomedical optics express · 2017Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a high resolution polarization sensitive optical coherence tomography (PS-OCT) system for ocular imaging in rodents. The system operates at 840 nm and uses a broadband superluminescent diode providing an axial resolution of 5.1 µm in air. PS-OCT data was acquired at 83 kHz A-scan rate by two identical custom-made spectrometers for orthogonal polarization states. Pigmented (Brown Norway, Long Evans) and non-pigmented (Sprague Dawley) rats as well as pigmented mice (C57BL/6) were imaged. Melanin pigment related depolarization was analyzed in the retinal pigment epithelium (RPE) and choroid of these animals using the degree of polarization uniformity (DOPU). For all rat strains, significant differences between RPE and choroidal depolarization were observed. In contrast, DOPU characteristics of RPE and choroid were similar for C57BL/6 mice. Moreover, the depolarization within the same tissue type varied significantly between different rodent strains. Retinal nerve fiber layer thickness, phase retardation, and birefringence were mapped and quantitatively measured in Long Evans rats in vivo for the first time. In a circumpapillary annulus, retinal nerve fiber layer birefringence amounted to 0.16°/µm ± 0.02°/µm and 0.17°/µm ± 0.01°/µm for the left and right eyes, respectively.
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