Evidence map›Paper›PMID 27446646›Full record

ArticleBiomedical optics express2016

Changes in autofluorescence based organoid model of muscle invasive urinary bladder cancer.

Scott Palmer, Karina Litvinova, Andrey Dunaev, Stewart Fleming, David McGloin, Ghulam Nabi

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Scott PalmerDivision of Imaging and Technology, University of Dundee, Ninewells Hospital and Medical School, James Arrott Drive, Dundee, DD1 9SY, UK.
Karina LitvinovaOptoelectronics and Biomedical Photonics Group, Aston Institute of Photonic Technologies, Aston University, Aston Triangle, Birmingham, B4 7ET, UK.
Andrey DunaevBiomedical Photonics Instrumentation Group, Scientific-Educational Centre of "Biomedical Engineering," State University - Education-Science-Production Complex, Oryol, 302020, Russia.
Stewart FlemingMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, James Arrott Drive, Dundee, DD1 9SY, UK.
David McGloinDivision of Electronic Engineering and Physics, Ewing Building, University of Dundee, Nethergate, Dundee, DD14HN, UK.
Ghulam NabiDivision of Imaging and Technology, University of Dundee, Ninewells Hospital and Medical School, James Arrott Drive, Dundee, DD1 9SY, UK.
University of Dundee · GBAston University · GBNinewells Hospital · GBOrel State University named after I.S. Turgenev · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Muscle invasive urinary bladder cancer is one of the most lethal cancers and its detection at the time of transurethral resection remains limited and diagnostic methods are urgently needed. We have developed a muscle invasive transitional cell carcinoma (TCC) model of the bladder using porcine bladder scaffold and the human bladder cancer cell line 5637. The progression of implanted cancer cells to muscle invasion can be monitored by measuring changes in the spectrum of endogenous fluorophores such as reduced nicotinamide dinucleotide (NADH) and flavins. We believe this could act as a useful tool for the study of fluorescence dynamics of developing muscle invasive bladder cancer in patients. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.

Indexed as

(000.1430) Biology and medicine(170.6510) Spectroscopy, tissue diagnostics

Identifiers

PMID27446646
PMCPMC4929632
OpenAlexW2298955746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.