Evidence map›Paper›PMID 27446449›Full record

ArticleOncology letters2016

Atorvastatin antagonizes the visfatin-induced expression of inflammatory mediators via the upregulation of NF-κB activation in HCAECs.

Kai-Lei Shi, Ju-Ying Qian, Lin Qi, Ding-Biao Mao, Yang Chen, Yi Zhu, Xin-Gui Guo

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kai-Lei ShiDepartment of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China.
Ju-Ying QianDepartment of Cardiology, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, P.R. China.
Lin QiDepartment of Radiology, Huadong Hospital Affiliated to Fudan Universtiy, Shanghai 200040, P.R. China.
Ding-Biao MaoDepartment of Radiology, Huadong Hospital Affiliated to Fudan Universtiy, Shanghai 200040, P.R. China.
Yang ChenDepartment of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China.
Yi ZhuDepartment of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China.
Xin-Gui GuoDepartment of Cardiology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China.
Huadong Hospital · CNFudan University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study investigated whether atorvastatin antagonizes the visfatin-induced expression of inflammatory mediators in human coronary artery endothelial cells (HCAECs). Several analysis methods, such as reverse transcription-quantitative polymerase chain reaction, western blot analysis and H

Indexed as

atorvastatinhuman coronary artery endothelial cellsnuclear factor-κBvisfatin

Identifiers

PMID27446449
PMCPMC4950623
OpenAlexW2474513370

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.