Evidence map›Paper›PMID 27446447›Full record

ArticleOncology letters2016

High expression levels of egfl7 correlate with low endothelial cell activation in peritumoral vessels of human breast cancer.

Diane Pannier, Géraldine Philippin-Lauridant, Marie-Christine Baranzelli, Delphine Bertin, Emilie Bogart, Victor Delprat, Gaëlle Villain, Virginie Mattot, Jacques Bonneterre, Fabrice Soncin

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Impact of Activation ofMedicina (Kaunas, Lithuania) · 2022
    Article
  2. Progress of EGFL6 in angiogenesis and tumor development.International journal of clinical and experimental pathology · 2022
    Review
  3. Review
  4. Article
  5. Article
  6. The emerging role of EGFL6 in angiogenesis and tumor progression.International journal of medical sciences · 2020
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Diane PannierSenology Department, Oscar Lambret Center, Université de Lille, 59020 Lille, France; Institut Pasteur de Lille, Centre National de la Recherche Scientifique UMR8161, Université de Lille, 59000 Lille, France.
Géraldine Philippin-LauridantSenology Department, Oscar Lambret Center, Université de Lille, 59020 Lille, France; Institut Pasteur de Lille, Centre National de la Recherche Scientifique UMR8161, Université de Lille, 59000 Lille, France.
Marie-Christine BaranzelliSenology Department, Oscar Lambret Center, Université de Lille, 59020 Lille, France.
Delphine BertinSenology Department, Oscar Lambret Center, Université de Lille, 59020 Lille, France.
Emilie BogartSenology Department, Oscar Lambret Center, Université de Lille, 59020 Lille, France.
Victor DelpratInstitut Pasteur de Lille, Centre National de la Recherche Scientifique UMR8161, Université de Lille, 59000 Lille, France.
Gaëlle VillainInstitut Pasteur de Lille, Centre National de la Recherche Scientifique UMR8161, Université de Lille, 59000 Lille, France.
Virginie MattotInstitut Pasteur de Lille, Centre National de la Recherche Scientifique UMR8161, Université de Lille, 59000 Lille, France.
Jacques BonneterreSenology Department, Oscar Lambret Center, Université de Lille, 59020 Lille, France.
Fabrice SoncinInstitut Pasteur de Lille, Centre National de la Recherche Scientifique UMR8161, Université de Lille, 59000 Lille, France.
Université de Lille · FRCentre Oscar Lambret · FRInstitut Pasteur de Lille · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor blood vessels participate in the immune response against cancer cells and we previously used pre-clinical models to demonstrate that egfl7 (VE-statin) promotes tumor cell evasion from the immune system by repressing endothelial cell activation, preventing immune cells from entering the tumor mass. In the present study, the expression levels of egfl7 and that of ICAM-1 as a marker of endothelium activation, were evaluated in peritumoral vessels of human breast cancer samples. Breast cancer samples (174 invasive and 30

Indexed as

blood vesselsbreast cancerendothelium activationimmunity

Identifiers

PMID27446447
PMCPMC4950557
OpenAlexW2471706537

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.