Evidence map›Paper›PMID 27446424›Full record

ArticleOncology letters2016

Xenograft models for undifferentiated pleomorphic sarcoma not otherwise specified are essential for preclinical testing of therapeutic agents.

Marc Becker, Claudine Graf, Marcus Tonak, Markus P Radsak, Tobias Bopp, Robert Bals, Rainer M Bohle, Matthias Theobald, Pol-Maria Rommens, Dirk Proschek and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Experimental models of undifferentiated pleomorphic sarcoma and malignant peripheral nerve sheath tumor.Laboratory investigation; a journal of technical methods and pathology · 2022
    Article
  2. Article
  3. Article
  4. Review
  5. CORR InsightsClinical orthopaedics and related research · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Marc BeckerInstitute of Pathology, Saarland University Medical Center, Homburg, Saarland D-66421, Germany; Interdisciplinary Sarcoma Working Group, Center of Orthopaedic and Trauma Surgery, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Rhineland-Palatinate D-5513, Germany.
Claudine GrafIII Department of Internal Medicine, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Rhineland-Palatinate D-55131, Germany.
Marcus TonakInterdisciplinary Sarcoma Working Group, Center of Orthopaedic and Trauma Surgery, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Rhineland-Palatinate D-5513, Germany; Department for Orthopaedic and Trauma Surgery, University Hospital Mannheim, Mannheim, Baden-Württemberg D-68167, Germany.
Markus P RadsakInstitute for Immunology, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Rhineland-Palatinate D-55131, Germany.
Tobias BoppInstitute for Immunology, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Rhineland-Palatinate D-55131, Germany.
Robert BalsDepartment of Internal Medicine V - Pulmonology, Allergology and Respiratory Critical Care Medicine, Saarland University Medical Center, Homburg, Saarland D-66421, Germany.
Rainer M BohleInstitute of Pathology, Saarland University Medical Center, Homburg, Saarland D-66421, Germany.
Matthias TheobaldIII Department of Internal Medicine, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Rhineland-Palatinate D-55131, Germany.
Pol-Maria RommensInterdisciplinary Sarcoma Working Group, Center of Orthopaedic and Trauma Surgery, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Rhineland-Palatinate D-5513, Germany.
Dirk ProschekInterdisciplinary Sarcoma Working Group, Center of Orthopaedic and Trauma Surgery, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Rhineland-Palatinate D-5513, Germany.
Thomas C WehlerIII Department of Internal Medicine, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Rhineland-Palatinate D-55131, Germany.
Johannes Gutenberg University Mainz · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DESaarland University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Undifferentiated pleomorphic sarcoma not otherwise specified belongs to the heterogeneous group of soft tissue tumors. It is preferentially located in the upper and lower extremities of the body, and surgical resection remains the only curative treatment. Preclinical animal models are crucial to improve the development of novel chemotherapeutic agents for the treatment of undifferentiated pleomorphic sarcoma. However, this approach has been hampered by the lack of reproducible animal models. The present study established two xenograft animal models generated from stable non-clonal cell cultures, and investigated the difference in chemotherapeutic effects on tumor growth between undifferentiated pleomorphic sarcoma

Indexed as

animal modeldoxorubicinHDAC inhibitorpazopanibpleomorphic sarcomaxenograft

Identifiers

PMID27446424
PMCPMC4950181
OpenAlexW2465905379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.