ArticleExperimental and therapeutic medicine2016
DKK1 inhibits proliferation and migration in human retinal pigment epithelial cells via the Wnt/β-catenin signaling pathway.
Article in Experimental and therapeutic medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- PANoptosis in diabetic retinopathy: immunological insights into mechanisms and translational therapies.Frontiers in immunology · 2026Review
- Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor.Nature biomedical engineering · 2024Article
- A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration.Cell genomics · 2023Article
- Extracellular Vesicles Released from Cancer Cells Promote Tumorigenesis by Inducing Epithelial to Mesenchymal Transition via β-Catenin Signaling.International journal of molecular sciences · 2023Article
- Glyphosate-based herbicide induces long-lasting impairment in neuronal and glial differentiation.Environmental toxicology · 2022Article
- DKK1 inhibits breast cancer cell migration and invasion through suppression of β-catenin/MMP7 signaling pathway.Cancer cell international · 2019Article
- LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p.Cancer cell international · 2019Article
- Plumbagin induces RPE cell cycle arrest and apoptosis via p38 MARK and PI3K/AKT/mTOR signaling pathways in PVR.BMC complementary and alternative medicine · 2018Article
- DLX3 Inhibits the Proliferation of Human Dental Pulp Cells Through Inactivation of Canonical Wnt/β-Catenin Signaling Pathway.Frontiers in physiology · 2018Article
- The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration.International journal of molecular sciences · 2018Review
- Spontaneous generation of a novel foetal human retinal pigment epithelium (RPE) cell line available for investigation on phagocytosis and morphogenesis.Cell proliferation · 2017Article
- Canonical Wnt signaling in diabetic retinopathy.Vision research · 2017Review
- miR-373-3p Targets DKK1 to Promote EMT-Induced Metastasis via the Wnt/BioMed research international · 2017Article
- The role of Dickkopf family in cancers: from Bench to Bedside.American journal of cancer research · 2017Review
- Pentazocine Protects SN4741 Cells Against MPPFrontiers in aging neuroscience · 2017Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal pigment epithelial (RPE) cells play important roles in diabetic retinopathy (DR). Dickkopf 1 (DKK1) has been reported to be important in the regulation of cell proliferation and migration. However, there are few previous studies regarding DKK1 in RPE cells. Therefore, in the present study, we investigated the effect of DKK1 on the proliferation and migration of human RPE cells, and the signaling mechanisms underlying these effects. The results showed that the overexpression of DKK1 significantly inhibited the proliferation and migration of ARPE-19 cells. In addition, overexpression of DKK1 markedly inhibited the expression of β-catenin and cyclin D1 in ARPE-19 cells. Collectively, the present findings suggest that the overexpression of DKK1 inhibited the proliferation and migration of RPE cells by suppressing the Wnt/β-catenin signaling pathway. Therefore, DKK1 are able to augment the growth of human RPE, and further studies are warranted to investigate the effects of DKK1 effects on DR.
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