ArticleFrontiers in microbiology2016
Diversity of Natural Product Biosynthetic Genes in the Microbiome of the Deep Sea Sponges Inflatella pellicula, Poecillastra compressa, and Stelletta normani.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- New insights into the microbiome of the deep-sea spongeMicrobial genomics · 2026Article
- Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential.FEMS microbes · 2023Article
- Diversity of Bacterial Secondary Metabolite Biosynthetic Gene Clusters in Three Vietnamese Sponges.Marine drugs · 2022Article
- Sponge holobionts shift their prokaryotic communities and antimicrobial activity from shallow to lower mesophotic depths.Antonie van Leeuwenhoek · 2022Article
- Bacteria Associated with Benthic Invertebrates from Extreme Marine Environments: Promising but Underexplored Sources of Biotechnologically Relevant Molecules.Marine drugs · 2022Review
- Cultivation of Sponge-Associated Bacteria fromMarine drugs · 2019Article
- Diversity of tryptophan halogenases in sponges of the genus Aplysina.FEMS microbiology ecology · 2019Article
- New Approaches to Detect Biosynthetic Gene Clusters in the Environment.Medicines (Basel, Switzerland) · 2019Review
- Temporal Stability of Bacterial Communities in Antarctic Sponges.Frontiers in microbiology · 2019Article
- Review
- Metabolome variability for two Mediterranean sponge species of the genus Haliclona: specificity, time, and space.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Diverse and Abundant Secondary Metabolism Biosynthetic Gene Clusters in the Genomes of Marine Sponge Derived Streptomyces spp. Isolates.Marine drugs · 2018Article
- Synthesis of Nm-PHB (nanomelanin-polyhydroxy butyrate) nanocomposite film and its protective effect against biofilm-forming multi drug resistant Staphylococcus aureus.Scientific reports · 2017Article
- Biotechnological Potential of Cold Adapted Pseudoalteromonas spp. Isolated from 'Deep Sea' Sponges.Marine drugs · 2017Article
- Marine biotechnology: diving deeper for drugs.Microbial biotechnology · 2017Article
- Article
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4 authors.
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Abstract
Three different deep sea sponge species, Inflatella pellicula, Poecillastra compressa, and Stelletta normani comprising seven individual samples, retrieved from depths of 760-2900 m below sea level, were investigated using 454 pyrosequencing for their secondary metabolomic potential targeting adenylation domain and ketosynthase domain sequences. The data obtained suggest a diverse microbial origin of nonribosomal peptide synthetases and polyketide synthase fragments that in part correlates with their respective microbial community structures that were previously described and reveals an untapped source of potential novelty. The sequences, especially the ketosynthase fragments, display extensive clade formations which are clearly distinct from sequences hosted in public databases, therefore highlighting the potential of the microbiome of these deep sea sponges to produce potentially novel small-molecule chemistry. Furthermore, sequence similarities to gene clusters known to be involved in the production of many classes of antibiotics and toxins including lipopeptides, glycopeptides, macrolides, and hepatotoxins were also identified.
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