ArticleFrontiers in microbiology2016
Microbial Dysbiosis: Rethinking Disease in Marine Ecosystems.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
100 citing papers in PubMed, 1 synthesis or guideline pooled it, 271 citations in OpenAlex.
- Omics-based insights into skin ulcerative disease in sea cucumbers: a systematic review.Molecular biology reports · 2025Pooled it
- Mariculture Probiotics: A Scoping Review of Research Trends, Knowledge Gaps and Opportunities.Marine biotechnology (New York, N.Y.) · 2026Article
- Bacterial Microbiota Signatures Suggest Acclimation of the Gorgonian Leptogorgia sarmentosa to Highly Impacted Environments in the Mediterranean Sea.Microbial ecology · 2026Article
- Seagrasses host unique and vulnerable microbiomes, structured by inter-domain microbial interactions.iScience · 2026Article
- Comparing Microbial Communities of Diseased and Healthy Isopora palifera Corals and Adjacent Waters at the Cocos (Keeling) Islands.Environmental microbiology · 2026Article
- Article
- NativePathogens (Basel, Switzerland) · 2026Article
- Bacterial disease in seaweed aquaculture: pathogen diversity and future solutions.Journal of applied phycology · 2026Review
- Nutrient-rich environments drive microbiome restructuring and mucus shedding in a coastal cnidarian.Frontiers in microbiology · 2026Article
- Too hot for my bugs: mediterranean heatwave disrupts associated microbiomes in the sponge Petrosia ficiformis.Environmental microbiome · 2025Article
- One Health, One Microbiome.Microbiome · 2025Review
- Near complete local extinction of iconic anemonefish and their anemone hosts following a heat stress event.npj biodiversity · 2025Article
- Whole-Genome-Sequencing Analysis of the Pathogen Causing Spotting Disease and Molecular Response in theMicroorganisms · 2025Article
- A computational framework for inferring species dynamics and interactions with applications in microbiota ecology.NPJ systems biology and applications · 2025Article
- Machine learning reveals distinct gene expression signatures across tissue states in stony coral tissue loss disease.Royal Society open science · 2025Article
- Advancements in Algal Microbiome Research: A Game-Changer for Climate Resilience and Invasion Success?Microbial ecology · 2025Review
- Jellyfish blooms through the microbial lens: temporal changes, cross-species and Jellyfish-water comparisons.Environmental microbiome · 2025Article
- Microbiota Dysbiosis inMicroorganisms · 2025Article
- Investigating the influence ofmSystems · 2025Article
- A review of quorum-sensing and its role in mediating interkingdom interactions in the ocean.Communications biology · 2025Review
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With growing environmental pressures placed on our marine habitats there is concern that the prevalence and severity of diseases affecting marine organisms will increase. Yet relative to terrestrial systems, we know little about the underlying causes of many of these diseases. Moreover, factors such as saprophytic colonizers and a lack of baseline data on healthy individuals make it difficult to accurately assess the role of specific microbial pathogens in disease states. Emerging evidence in the field of medicine suggests that a growing number of human diseases result from a microbiome imbalance (or dysbiosis), questioning the traditional view of a singular pathogenic agent. Here we discuss the possibility that many diseases seen in marine systems are, similarly, the result of microbial dysbiosis and the rise of opportunistic or polymicrobial infections. Thus, understanding and managing disease in the future will require us to also rethink definitions of disease and pathogenesis for marine systems. We suggest that a targeted, multidisciplinary approach that addresses the questions of microbial symbiosis in both healthy and diseased states, and at that the level of the holobiont, will be key to progress in this area.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.