ArticleFrontiers in microbiology2016
Limited Specificity in the Injury and Infection Priming against Bacteria in Aedes aegypti Mosquitoes.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- When Small Meets Smaller: Immune Modulation and Virulence Strategies in Insect-Bacteria Interactions.Insects · 2026Review
- Response of the mosquito immune system and symbiotic bacteria to pathogen infection.Parasites & vectors · 2024Review
- The costs of transgenerational immune priming for homologous and heterologous infections with different serotypes of dengue virus inFrontiers in immunology · 2023Article
- Efficient Oral Priming ofVaccines · 2022Article
- Pre-exposure toFrontiers in microbiology · 2022Article
- Seminal fluid proteins induce transcriptome changes in the Aedes aegypti female lower reproductive tract.BMC genomics · 2021Article
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Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Injury and infection priming has been observed in several insect groups, reported as host immune protection against contact with a pathogen caused by a previous infection with the same. However, the specific response against a pathogen has not been demonstrated in all insect species. Investigating the specific priming response in insects is important because their immune strategies probably reflect particular selective pressures exerted by different pathogens. Here, we determined whether previous infection of Aedes aegypti would enhance survival and/or lead to greater and specific AMP expression after a second exposure to the same or a distinct bacterium. Mosquitoes previously immunized with a low dose of Escherichia coli, but not Staphylococcus aureus, showed increased survival. Although the host protection herein demonstrated was not specific, each bacterium elicited differential AMP expression. These results can be explained by the susceptible-primed-infected (SPI) epidemiological model, which poses that in the evolution of memory-like responses (priming), a pivotal role is played by pathogen virulence, associated host damage, and the host capacity of pathogen recognition.
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