ArticleFrontiers in endocrinology2016
MyomiRs as Markers of Insulin Resistance and Decreased Myogenesis in Skeletal Muscle of Diet-Induced Obese Mice.
Article in Frontiers in endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
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- Cord Blood Exosomal miRNAs from Small-for-Gestational-Age Newborns: Association with Measures of PostnatalInternational journal of molecular sciences · 2025Article
- Review
- Comparative effects of metformin and varying intensities of exercise on miR-133a expression in diabetic rats: Insights from machine learning analysis.Biochemistry and biophysics reports · 2024Article
- Glucocorticoid modulates oxidative and thermogenic function of rat brown adipose tissue and human brown adipocytes.Journal of cellular physiology · 2024Article
- Regulation and mechanism of action of miRNAs on insulin resistance in skeletal muscles.Non-coding RNA research · 2023Review
- Pharmaceutical Agents for Contractile-Metabolic Dysfunction After Volumetric Muscle Loss.Tissue engineering. Part A · 2022Article
- Esophageal striated muscle hypertrophy and muscle fiber type transformation in MSTN knockout pigs.Transgenic research · 2022Article
- Extracellular miRNAs as mediators of obesity-associated disease.The Journal of physiology · 2022Review
- PDIA4, a new endoplasmic reticulum stress protein, modulates insulin resistance and inflammation in skeletal muscle.Frontiers in endocrinology · 2022Article
- Palmitic Acid Impairs Myogenesis and Alters Temporal Expression of miR-133a and miR-206 in C2C12 Myoblasts.International journal of molecular sciences · 2021Article
- Expression and clinical significance of miR-1 and miR-133 in pre-diabetes.Biomedical reports · 2021Article
- Centennial Review: Metabolic microRNA - shifting gears in the regulation of metabolic pathways in poultry.Poultry science · 2021Review
- Recent advances and future avenues in understanding the role of adipose tissue cross talk in mediating skeletal muscle mass and function with ageing.GeroScience · 2021Review
- Intramuscular Injection of miR-1 Reduces Insulin Resistance in Obese Mice.Frontiers in physiology · 2021Article
- The Changes of Heart miR-1 and miR-133 Expressions following Physiological Hypertrophy Due to Endurance Training.Cell journal · 2020Article
- Association of Genetic Polymorphisms in MicroRNAs With Type 2 Diabetes Mellitus in a Chinese Population.Frontiers in endocrinology · 2020Article
- Non and Epigenetic Mechanisms in Regulation of Adaptive Thermogenesis in Skeletal Muscle.Frontiers in endocrinology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-fat diet (HFD) feeding causes insulin resistance (IR) in skeletal muscle of mice, which affects skeletal muscle metabolism and function. The involvement of muscle-specific microRNAs in the evolution of skeletal muscle IR during 4, 8, and 12 weeks in HFD-induced obese mice was investigated. After 4 weeks in HFD, mice were obese, hyperglycemic, and hyperinsulinemic; however, their muscles were responsive to insulin stimuli. Expressions of MyomiRs (miR-1, miR-133a, and miR-206) measured in soleus muscles were not different from those found in control mice. After 8 weeks of HFD feeding, glucose uptake was lower in skeletal muscle from obese mice compared to control mice, and we observed a significant decrease in miR-1a in soleus muscle when compared to HFD for 4 weeks. miR-1a expression continued to decay within time. After 12 weeks of HFD, miR-133a expression was upregulated when compared to the control group. Expression of miR-1a was negatively correlated with glycemia and positively correlated with the constant rate of plasma glucose disappearance. Pioglitazone treatment could not reverse decreases of miR-1a levels induced by HFD. Targets of myomiRs involved in insulin-growth factor (IGF)-1 pathway, such as Igf-1, Irs-1, Rheb, and follistatin, were reduced after 12 weeks in HFD and Mtor increased, when compared to the control or HFD for 4 or 8 weeks. These findings suggest for the first time that miR-1 may be a marker of the development of IR in skeletal muscle. Evidence was also presented that impairment in myomiRs expression contributes to decreased myogenesis and skeletal muscle growth reported in diabetes.
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