ArticleFrontiers in physiology2016
Sickness Behavior in Honey Bees.
Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 59 citations in OpenAlex.
- Large-Scale Data Analysis of Post-Traumatic Stress Disorder (PTSD) Through GWAS Fine-Mapping and Systems Biology.Journal of personalized medicine · 2026Article
- Buzzed but not elated? Effect of ethanol on cognitive judgement bias in honeybees.Animal cognition · 2026Article
- Phytoplasma infection induces changes in vibrational signals of Cacopsylla pyri: sex-specific shifts in frequency, amplitude, and timing.BMC zoology · 2026Article
- Distributed Artificial Intelligence for Organizational and Behavioral Recognition of Bees and Ants.Sensors (Basel, Switzerland) · 2026Article
- Low motivation drives poor performance of infected, anorexic crows on a string-pulling task.Animal cognition · 2025Article
- Equine Social Behaviour: Love, War and Tolerance.Animals : an open access journal from MDPI · 2023Review
- Host genetics and pathogen species modulate infection-induced changes in social aggregation behaviour.Biology letters · 2022Article
- Viral infection changes the expression of personality traits in an insect species reared for consumption.Scientific reports · 2022Article
- Antennal movements can be used as behavioral readout of odor valence in honey bees.IBRO neuroscience reports · 2022Article
- Social networks respond to a disease challenge in calves.Scientific reports · 2022Article
- Sick bats stay home alone: fruit bats practice social distancing when faced with an immunological challenge.Annals of the New York Academy of Sciences · 2021Article
- Immune challenges increase network centrality in a queenless ant.Proceedings. Biological sciences · 2021Article
- Endorphinergic Enhancement Attenuation of Post-traumatic Stress Disorder (PTSD)Current psychopharmacology · 2021Article
- How territoriality reduces disease transmission among social insect colonies.Behavioral ecology and sociobiology · 2021Article
- No evidence of sickness behavior in immune-challenged field crickets.Ecology and evolution · 2020Article
- The Contribution of Sociocultural Factors in Shaping Self-Reported Sickness Behavior.Frontiers in behavioral neuroscience · 2020Article
- The transcriptomic signature of low aggression in honey bees resembles a response to infection.BMC genomics · 2019Article
- Relevance of number and physiological status of conspecifics in preventing stress-induced decreases in newly proliferated cells and neuroblasts.Psychopharmacology · 2019Article
- Viral infection causes sex-specific changes in fruit fly social aggregation behaviour.Biology letters · 2019Article
- Viral infections in fire ants lead to reduced foraging activity and dietary changes.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During an infection, animals suffer several changes in their normal physiology and behavior which may include lethargy, appetite loss, and reduction in grooming and general movements. This set of alterations is known as sickness behavior and although it has been extensively believed to be orchestrated primarily by the immune system, a relevant role for the central nervous system has also been established. The aim of the present work is to develop a simple animal model to allow studying how the immune and the nervous systems interact coordinately during an infection. We administered a bacterial lipopolysaccharide (LPS) into the thorax of honey bees to mimic a bacterial infection, and then we evaluated a set of stereotyped behaviors of the animals that might be indicative of sickness behavior. First, we show that this immune challenge reduces the locomotor activity of the animals in a narrow time window after LPS injection. Furthermore, bees exhibit a loss of appetite 60 and 90 min after injection, but not 15 h later. We also demonstrate that LPS injection reduces spontaneous antennal movements in harnessed animals, which suggests a reduction in the motivational state of the bees. Finally, we show that the LPS injection diminishes the interaction between animals, a crucial behavior in social insects. To our knowledge these results represent the first systematic description of sickness behavior in honey bees and provide important groundwork for the study of the interaction between the immune and the neural systems in an insect model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.