ArticleFrontiers in physiology2016
Muscle Fatigue Affects the Interpolated Twitch Technique When Assessed Using Electrically-Induced Contractions in Human and Rat Muscles.
Article in Frontiers in physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Acute acetaminophen ingestion improves performance and muscle activation during maximal intermittent knee extensor exercise.European journal of applied physiology · 2018Trial
- Caffeine ingestion improves morning neuromuscular performance to evening levels in healthy females.PloS one · 2026Article
- Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions.Aging and disease · 2024Review
- Are Surface Electromyography Parameters Indicative of Post-Activation Potentiation/Post-Activation Performance Enhancement, in Terms of Twitch Potentiation and Voluntary Performance? A Systematic Review.Journal of functional morphology and kinesiology · 2024Review
- Electrophysiology Methods for Assessing of Neurodegenerative and Post-Traumatic Processes as Applied to Translational Research.Life (Basel, Switzerland) · 2024Review
- Effects of three neuromuscular electrical stimulation methods on muscle force production and neuromuscular fatigue.Scandinavian journal of medicine & science in sports · 2022Article
- Quantification of central fatigue: a central debate.European journal of applied physiology · 2021Article
- On the reliability and validity of central fatigue determination.European journal of applied physiology · 2021Review
- Muscle Contractile Characteristics During Exhaustive Dynamic Exercise and Recovery.Frontiers in physiology · 2021Article
- Unlike voluntary contractions, stimulated contractions of a hand muscle do not reduce voluntary activation or motoneuronal excitability.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Sex differences in muscle activity emerge during sustained low-intensity contractions but not during intermittent low-intensity contractions.Physiological reports · 2020Article
- Quantification of Neuromuscular Fatigue: What Do We Do Wrong and Why?Sports medicine (Auckland, N.Z.) · 2020Article
- Neuromuscular Factors Contributing to Reductions in Muscle Force After Repeated, High-Intensity Muscular Efforts.Frontiers in physiology · 2019Article
- Effects of a Finger Tapping Fatiguing Task on M1-Intracortical Inhibition and Central Drive to the Muscle.Scientific reports · 2018Article
- Neurophysiological Mechanisms Underpinning Stretch-Induced Force Loss.Sports medicine (Auckland, N.Z.) · 2017Review
- Intramuscular Contributions to Low-Frequency Force Potentiation Induced by a High-Frequency Conditioning Stimulation.Frontiers in physiology · 2017Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interpolated twitch technique (ITT) is the gold standard to assess voluntary activation and central fatigue. Yet, its validity has been questioned. Here we studied how peripheral fatigue can affect the ITT. Repeated contractions at submaximal frequencies were produced by supramaximal electrical stimulations of the human adductor pollicis muscle in vivo and of isolated rat soleus fiber bundles; an extra stimulation pulse was given during contractions to induce a superimposed twitch. Human muscles fatigued by repeated 30-Hz stimulation trains (3 s on-1 s off) showed an ~80% reduction in the superimposed twitch force accompanied by a severely reduced EMG response (M-wave amplitude), which implies action potential failure. Subsequent experiments combined a less intense stimulation protocol (1.5 s on-3 s off) with ischemia to cause muscle fatigue, but which preserved M-wave amplitude. However, the superimposed twitch force still decreased markedly more than the potentiated twitch force; with ITT this would reflect increased "voluntary activation." In contrast, the superimposed twitch force was relatively spared when a similar protocol was performed in rat soleus bundles. Force relaxation was slowed by >150% in fatigued human muscles, whereas it was unchanged in rat soleus bundles. Accordingly, results similar to those in the human muscle were obtained when relaxation was slowed by cooling the rat soleus muscles. In conclusion, our data demonstrate that muscle fatigue can confound the quantification of central fatigue using the ITT.
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