Evidence map›Paper›PMID 27445812›Full record

ArticleFrontiers in pharmacology2016

Effects of Benzodiazepines on Acinar and Myoepithelial Cells.

Tatiana M F Mattioli, Luciana R A Alanis, Silvana da Silva Sapelli, Antonio A S de Lima, Lucia de Noronha, Edvaldo A R Rosa, Yusuf S Althobaiti, Atiah H Almalki, Youssef Sari, Sergio A Ignacio and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Tatiana M F MattioliPharmacology and Experimental Pathology, School of Dentistry, Pontifical Catholic University of Paraná Curitiba, Brazil.
Luciana R A AlanisProgram of Post-Graduation, School of Dentistry, Health and Bioscience School, Pontifical Catholic University of Paraná Curitiba, Brazil.
Silvana da Silva SapelliPharmacology and Experimental Pathology, School of Dentistry, Pontifical Catholic University of Paraná Curitiba, Brazil.
Antonio A S de LimaDepartment of Oral Pathology, School of Dentistry, Federal University of Paraná Curitiba, Brazil.
Lucia de NoronhaProgram of Post-Graduation, Department of Pathology, School of Medicine, Pontifical Catholic University of Paraná Curitiba, Brazil.
Edvaldo A R RosaProgram of Post-Graduation, School of Dentistry, Health and Bioscience School, Pontifical Catholic University of Paraná Curitiba, Brazil.
Yusuf S AlthobaitiDepartment of Pharmacology, College of Pharmacy and Pharmaceutical, The University of Toledo Toledo, OH, US.
Atiah H AlmalkiDepartment of Pharmacology, College of Pharmacy and Pharmaceutical, The University of Toledo Toledo, OH, US.
Youssef SariDepartment of Pharmacology, College of Pharmacy and Pharmaceutical, The University of Toledo Toledo, OH, US.
Sergio A IgnacioProgram of Post-Graduation, School of Dentistry, Health and Bioscience School, Pontifical Catholic University of Paraná Curitiba, Brazil.
Aline C B R JohannProgram of Post-Graduation, School of Dentistry, Health and Bioscience School, Pontifical Catholic University of Paraná Curitiba, Brazil.
Ana M T GregioDepartment of Pharmacology, College of Pharmacy and Pharmaceutical, The University of ToledoToledo, OH, US; Program of Post-Graduation, Department of Pharmacology, School of Dentistry, Health and Bioscience School, Pontifical Catholic University of ParanáCuritiba, Brazil.
Pontifícia Universidade Católica do Paraná · BRUniversity of Toledo · USUniversidade Federal do Paraná · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBenzodiazepines (BZDs), the most commonly prescribed psychotropic drugs with anxiolytic action, may cause hyposalivation. It has been previously shown that BZDs can cause hypertrophy and decrease the acini cell number. In this study, we investigated the effects of BZDs and pilocarpine on rat parotid glands, specifically on acinar, ductal, and myoepithelial cells.

methodsNinety male Wistar rats were divided into nine groups. Control groups received a saline solution for 30 days (C30) and 60 days (C60), and pilocarpine (PILO) for 60 days. Experimental groups received lorazepam (L30) and midazolam (M30) for 30 days. Another group (LS60 or MS60) received lorazepam or midazolam for 30 days, respectively, and saline for additional 30 days. Finally, other groups (LP60 or MP60) received either lorazepam or midazolam for 30 days, respectively, and pilocarpine for additional 30 days. The expression of calponin in myoepithelial cells and the proliferating cell nuclear antigen (PCNA) in acinar and ductal cells were evaluated.

resultsAnimals treated with lorazepam showed an increase in the number of positive staining cells for calponin as compared to control animals (p < 0.05). Midazolam administered with pilocarpine (MP60) induced an increase in the proliferation of acinar and ductal cells and a decrease in the positive staining cells for calponin as compared to midazolam administered with saline (MS60).

conclusionWe found that myoepithelial cells might be more sensitive to the effects of BZD than acinar and ductal cells in rat parotid glands.

Indexed as

benzodiazepinesdry mouthGABAA receptorimmunohistochemistrysalivary glands

Identifiers

PMID27445812
PMCPMC4919344
OpenAlexW2467828823

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.