Evidence map›Paper›PMID 27445782›Full record

ReviewFrontiers in computational neuroscience2016

fMRI at High Spatial Resolution: Implications for BOLD-Models.

Jozien Goense, Yvette Bohraus, Nikos K Logothetis

Abstract readReview
In one paragraph

Review in Frontiers in computational neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed.

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  18. Review
  19. The many layers of BOLD. The effect of hypercapnic and hyperoxic stimuli on macro- and micro-vascular compartments quantified byJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
  20. Laminar VASO fMRI in focal hand dystonia patients.Dystonia (Lausanne, Switzerland) · 2023
    Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jozien GoenseDepartment of Psychology, Institute of Neuroscience and Psychology, University of Glasgow Glasgow, UK.
Yvette BohrausDepartment of Physiology of Cognitive Processes, Max-Planck Institute for Biological Cybernetics Tübingen, Germany.
Nikos K LogothetisDepartment of Physiology of Cognitive Processes, Max-Planck Institute for Biological CyberneticsTübingen, Germany; Divison of Imaging Science and Biomedical Engineering, University of ManchesterManchester, UK.

Funding

Medical Research Council MR/N003403/1
6 · The paper itself

Abstract

As high-resolution functional magnetic resonance imaging (fMRI) and fMRI of cortical layers become more widely used, the question how well high-resolution fMRI signals reflect the underlying neural processing, and how to interpret laminar fMRI data becomes more and more relevant. High-resolution fMRI has shown laminar differences in cerebral blood flow (CBF), volume (CBV), and neurovascular coupling. Features and processes that were previously lumped into a single voxel become spatially distinct at high resolution. These features can be vascular compartments such as veins, arteries, and capillaries, or cortical layers and columns, which can have differences in metabolism. Mesoscopic models of the blood oxygenation level dependent (BOLD) response therefore need to be expanded, for instance, to incorporate laminar differences in the coupling between neural activity, metabolism and the hemodynamic response. Here we discuss biological and methodological factors that affect the modeling and interpretation of high-resolution fMRI data. We also illustrate with examples from neuropharmacology and the negative BOLD response how combining BOLD with CBF- and CBV-based fMRI methods can provide additional information about neurovascular coupling, and can aid modeling and interpretation of high-resolution fMRI.

Indexed as

BOLD mechanismcerebral blood flowcerebral blood volumecortical layershigh-resolution fMRIneurovascular coupling

Identifiers

PMID27445782
PMCPMC4923185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.