ArticleFrontiers in computational neuroscience2016
Computational Modeling of Single Neuron Extracellular Electric Potentials and Network Local Field Potentials using LFPsim.
Article in Frontiers in computational neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 70 citations in OpenAlex.
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- Multiscale model of primary motor cortex circuits predicts in vivo cell-type-specific, behavioral state-dependent dynamics.Cell reports · 2023Article
- Intensity- and frequency-specific effects of transcranial alternating current stimulation are explained by network dynamics.bioRxiv : the preprint server for biology · 2023Article
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- A phenomenological computational model of the evoked action potential fitted to human cochlear implant responses.PLoS computational biology · 2022Article
- Large-scale biophysically detailed model of somatosensory thalamocortical circuits in NetPyNE.Frontiers in neuroinformatics · 2022Article
- Discovering Microcircuit Secrets With Multi-Spot Imaging and Electrophysiological Recordings: The Example of Cerebellar Network Dynamics.Frontiers in cellular neuroscience · 2022Review
- Gamma Oscillations in the Basolateral Amygdala: Localization, Microcircuitry, and Behavioral Correlates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Microcircuit mechanisms for the generation of sharp-wave ripples in the basolateral amygdala: A role for chandelier interneurons.Cell reports · 2021Article
- Modeling nucleus accumbens : A Computational Model from Single Cell to Circuit Level.Journal of computational neuroscience · 2021Article
- Quantification of Epileptogenic Network From Stereo EEG Recordings Using Epileptogenicity Ranking Method.Frontiers in neurology · 2021Article
- Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review.Bioelectricity · 2020Review
- Fast simulation of extracellular action potential signatures based on a morphological filtering approximation.Journal of computational neuroscience · 2020Article
- Reduced order models of myelinated axonal compartments.Journal of computational neuroscience · 2019Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Local Field Potentials (LFPs) are population signals generated by complex spatiotemporal interaction of current sources and dipoles. Mathematical computations of LFPs allow the study of circuit functions and dysfunctions via simulations. This paper introduces LFPsim, a NEURON-based tool for computing population LFP activity and single neuron extracellular potentials. LFPsim was developed to be used on existing cable compartmental neuron and network models. Point source, line source, and RC based filter approximations can be used to compute extracellular activity. As a demonstration of efficient implementation, we showcase LFPs from mathematical models of electrotonically compact cerebellum granule neurons and morphologically complex neurons of the neocortical column. LFPsim reproduced neocortical LFP at 8, 32, and 56 Hz via current injection, in vitro post-synaptic N2a, N2b waves and in vivo T-C waves in cerebellum granular layer. LFPsim also includes a simulation of multi-electrode array of LFPs in network populations to aid computational inference between biophysical activity in neural networks and corresponding multi-unit activity resulting in extracellular and evoked LFP signals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.