ArticleFrontiers in human neuroscience2016
Comparing Aging and Fitness Effects on Brain Anatomy.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Ultrafast fMRI Detects Age-Related Changes in Harmonics of Cardiac Pulsations in the Brain at 7 T.Magnetic resonance in medicine · 2026Article
- Ultrafast fMRI detects age-related changes in harmonics of cardiac pulsations in the brain at 7 T.bioRxiv : the preprint server for biology · 2025Article
- Effects of Aging, Estimated Fitness, and Cerebrovascular Status on White Matter Microstructural Health.Human brain mapping · 2025Article
- Cardiorespiratory fitness, hippocampal subfield morphology, and episodic memory in older adults.Frontiers in aging neuroscience · 2024Article
- Influence of Strenuous Physical Activity and Cardiorespiratory Fitness on Age-Related Differences in Brain Activations During Varieties of Cognitive Control.Neuroscience · 2023Article
- The Combined Influences of Exercise, Diet and Sleep on Neuroplasticity.Frontiers in psychology · 2022Review
- Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling.Brain plasticity (Amsterdam, Netherlands) · 2022Review
- A healthy mind in a healthy body: Effects of arteriosclerosis and other risk factors on cognitive aging and dementia.The psychology of learning and motivation · 2022Article
- Aerobic exercise, cardiorespiratory fitness, and the human hippocampus.Hippocampus · 2021Review
- Age-related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review.Psychophysiology · 2021Review
- Aging and cerebrovascular health: Structural, functional, cognitive, and methodological implications.Psychophysiology · 2021Article
- Thalamic volume mediates associations between cardiorespiratory fitness (VOParkinsonism & related disorders · 2021Article
- Midlife aerobic exercise and brain structural integrity: Associations with age and cardiorespiratory fitness.NeuroImage · 2021Article
- Investigating impact of cardiorespiratory fitness in reducing brain tissue loss caused by ageing.Brain communications · 2021Article
- Age-related differences in functional brain network segregation are consistent with a cascade of cerebrovascular, structural, and cognitive effects.Network neuroscience (Cambridge, Mass.) · 2020Article
- Fitness Level Influences White Matter Microstructure in Postmenopausal Women.Frontiers in aging neuroscience · 2020Article
- Age-Related Alterations in Brain Perfusion, Venous Oxygenation, and Oxygen Metabolic Rate of Mice: A 17-Month Longitudinal MRI Study.Frontiers in neurology · 2020Article
- Cerebral Arterial Pulsatility and Global White Matter Microstructure Impact Spatial Working Memory in Older Adults With and Without Cardiovascular Risk Factors.Frontiers in aging neuroscience · 2020Article
- Optical measures of cerebral arterial stiffness are associated with white matter signal abnormalities and cognitive performance in normal aging.Neurobiology of aging · 2019Article
- The Optical Effective Attenuation Coefficient as an Informative Measure of Brain Health in Aging.Photonics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies suggest that cardiorespiratory fitness (CRF) mitigates the brain's atrophy typically associated with aging, via a variety of beneficial mechanisms. One could argue that if CRF is generally counteracting the negative effects of aging, the same regions that display the greatest age-related volumetric loss should also show the largest beneficial effects of fitness. To test this hypothesis we examined structural MRI data from 54 healthy older adults (ages 55-87), to determine the overlap, across brain regions, of the profiles of age and fitness effects. Results showed that lower fitness and older age are associated with atrophy in several brain regions, replicating past studies. However, when the profiles of age and fitness effects were compared using a number of statistical approaches, the effects were not entirely overlapping. Interestingly, some of the regions that were most influenced by age were among those not influenced by fitness. Presumably, the age-related atrophy occurring in these regions is due to factors that are more impervious to the beneficial effects of fitness. Possible mechanisms supporting regional heterogeneity may include differential involvement in motor function, the presence of adult neurogenesis, and differential sensitivity to cerebrovascular, neurotrophic and metabolic factors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.