ArticleFrontiers in neuroanatomy2016
Progress Towards Mammalian Whole-Brain Cellular Connectomics.
Article in Frontiers in neuroanatomy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A canine brain bank for comparative neuroscience and brain aging research.bioRxiv : the preprint server for biology · 2026Article
- Scaling up X-ray holographic nanotomography for neuronal tissue imaging.Biomedical optics express · 2025Article
- Comparative prospects of imaging methods for whole-brain mammalian connectomics.Cell reports methods · 2025Review
- A technology platform for standardized cryoprotection and freezing of large-volume brain tissues for high-resolution histology.Frontiers in neuroanatomy · 2023Article
- U-RISC: An Annotated Ultra-High-Resolution Electron Microscopy Dataset Challenging the Existing Deep Learning Algorithms.Frontiers in computational neuroscience · 2022Article
- The Brain Observatory Storage Service and Database (BossDB): A Cloud-Native Approach for Petascale Neuroscience Discovery.Frontiers in neuroinformatics · 2022Article
- Cellular connectomes as arbiters of local circuit models in the cerebral cortex.Nature communications · 2021Article
- Upscaling X-ray nanoimaging to macroscopic specimens.Journal of applied crystallography · 2021Review
- Editorial: Electron-Microscopy-Based Tools for Imaging Cellular Circuits and Organisms.Frontiers in neural circuits · 2019Article
- A Student's Guide to Neural Circuit Tracing.Frontiers in neuroscience · 2019Review
- Large-Area Fluorescence and Electron Microscopic Correlative Imaging With Multibeam Scanning Electron Microscopy.Frontiers in neural circuits · 2019Article
- A carbon nanotube tape for serial-section electron microscopy of brain ultrastructure.Nature communications · 2018Article
- Total Number Is Important: Using the Disector Method in Design-Based Stereology to Understand the Structure of the Rodent Brain.Frontiers in neuroanatomy · 2018Review
- Network-based approaches to quantify multicellular development.Journal of the Royal Society, Interface · 2017Review
- Mesoscale imaging with cryo-light and X-rays: Larger than molecular machines, smaller than a cell.Biology of the cell · 2017Review
- Connectomics: A pharmacologic viewpoint.Indian journal of pharmacologyArticle
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1 author.
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Abstract
Neurons are the fundamental structural units of the nervous system-i.e., the Neuron Doctrine-as the pioneering work of Santiago Ramón y Cajal in the 1880's clearly demonstrated through careful observation of Golgi-stained neuronal morphologies. However, at that time sample preparation, imaging methods and computational tools were either nonexistent or insufficiently developed to permit the precise mapping of an entire brain with all of its neurons and their connections. Some measure of the "mesoscopic" connectional organization of the mammalian brain has been obtained over the past decade by alignment of sparse subsets of labeled neurons onto a reference atlas or via MRI-based diffusion tensor imaging. Neither method, however, provides data on the complete connectivity of all neurons comprising an individual brain. Fortunately, whole-brain cellular connectomics now appears within reach due to recent advances in whole-brain sample preparation and high-throughput electron microscopy (EM), though substantial obstacles remain with respect to large volume electron microscopic acquisitions and automated neurite reconstructions. This perspective examines the current status and problems associated with generating a mammalian whole-brain cellular connectome and argues that the time is right to launch a concerted connectomic attack on a small mammalian whole-brain.
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