ArticleFrontiers in neuroscience2016
Fascicular Topography of the Human Median Nerve for Neuroprosthetic Surgery.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 73 citations in OpenAlex.
- A methodological framework for the efficient characterization of peripheral nerve stimulation parameters.Journal of neural engineering · 2025Trial
- Selective neural electrical stimulation restores hand and forearm movements in individuals with complete tetraplegia.Journal of neuroengineering and rehabilitation · 2020Trial
- Sexual Dimorphism and Population Variation in Median Nerve Morphometry: A Multi-Institutional Cadaveric Analysis.Diagnostics (Basel, Switzerland) · 2026Article
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Decoding phantom limb movements from intraneural recordings.Nature communications · 2026Article
- Clinical Anatomy and Diagnostic Challenges in Peripheral Nerve Trauma for the Forensic Physician.Diagnostics (Basel, Switzerland) · 2025Review
- Fascicle differentiation of upper extremity nerves on high-resolution ultrasound with multimodal microscopic verification.Scientific reports · 2025Article
- Characterization of Machine Learning-Based Surrogate Models of Neural Activation Under Electrical Stimulation.Bioelectromagnetics · 2025Article
- Epineural stimulation on distal brachial plexus for functional restoration of the upper limb in a primate study.Frontiers in neurology · 2025Article
- Median nerve lesions in pediatric displaced supracondylar humerus fracture: A prospective neurological, electrodiagnostic and ultrasound characterization.European journal of neurology · 2024Article
- 3D fascicular reconstruction of median and ulnar nerve: initial experience and comparison between high-resolution ultrasound and MR microscopy.European radiology experimental · 2024Article
- Radial Nerve Palsy Caused by Desmoid-Type Fibromatosis: A Case Report and Review of the Literature.Cureus · 2024Article
- Using Compound Neural Action Potentials for Functional Validation of a High-Density Intraneural Interface: A Preliminary Study.Micromachines · 2024Article
- System of Implantable Electrodes for Neural Signal Acquisition and Stimulation for Wirelessly Connected Forearm Prosthesis.Biosensors · 2024Article
- Median neuropathy after multiple punctures of the forearm for catheterization: A case report.World journal of clinical cases · 2023Article
- Correlation between diffusion tensor indices and fascicular morphometric parameters of peripheral nerve.Frontiers in physiology · 2023Article
- Activating effective functional hand movements in individuals with complete tetraplegia through neural stimulation.Scientific reports · 2022Article
- Clinical Basis for Creating an Osseointegrated Neural Interface.Frontiers in neuroscience · 2022Article
- Bionic Prostheses: The Emerging Alternative to Vascularised Composite Allotransplantation of the Limb.Frontiers in surgery · 2022Review
- New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses.Sensors (Basel, Switzerland) · 2021Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the most sought-after applications of neuroengineering is the communication between the arm and an artificial prosthetic device for the replacement of an amputated hand or the treatment of peripheral nerve injuries. For that, an electrode is placed around or inside the median nerve to serve as interface for recording and stimulation of nerve signals coming from the fascicles that innervate the muscles responsible for hand movements. Due to the lack of a standard procedure, the electrode implantation by the surgeon is strongly based on intuition, which may result in poor performance of the neuroprosthesis because of the suboptimal location of the neural interface. To provide morphological data that can aid the neuroprosthetic surgeon with this procedure, we investigated the fascicular topography of the human median nerve along the forearm and upper arm. We first performed a description of the fascicular content and branching patterns along the length of the arm. Next we built a 3D reconstruction of the median nerve so we could analyze the fascicle morphological features in relation to the arm level. Finally, we characterized the motor content of the median nerve fascicles in the upper arm. Collectively, these results indicate that fascicular organization occurs in a short segment distal to the epicondyles and remains unaltered until the muscular branches leave the main trunk. Based on our results, overall recommendations based on electrode type and implant location can be drawn to help and aid the neuroprosthetic procedure. Invasive interfaces would be more convenient for the upper arm and the most proximal third of the forearm. Epineural electrodes seem to be most suitable for the forearm segment after fascicles have been divided from the main trunk.
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