ArticleFrontiers in neuroscience2016
Closed-Loop Neuroprosthesis for Reach-to-Grasp Assistance: Combining Adaptive Multi-channel Neuromuscular Stimulation with a Multi-joint Arm Exoskeleton.
Article in Frontiers in neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- EEG-timed neuromuscular stimulation shapes ipsilateral TMS-evoked motor responses in humans.Clinical neurophysiology practice · 2026Article
- A Comparative Study of Conventional and Tripolar EEG for High-Performance Reach-to-Grasp BCI Systems.IEEE transactions on bio-medical engineering · 2026Article
- Ethical gaps in closed-loop neurotechnology: a scoping review.NPJ digital medicine · 2025Article
- Wavelet Analysis of Noninvasive EEG Signals Discriminates Complex and Natural Grasp Types.ArXiv · 2025Article
- Avoidance of specific calibration sessions in motor intention recognition for exoskeleton-supported rehabilitation through transfer learning on EEG data.Scientific reports · 2024Article
- Cortical processing during robot and functional electrical stimulation.Frontiers in systems neuroscience · 2023Article
- Biomechanical Assessment of Post-Stroke Patients' Upper Limb before and after Rehabilitation Therapy Based on FES and VR.Sensors (Basel, Switzerland) · 2022Article
- Clinical validation of kinematic assessments of post-stroke upper limb movements with a multi-joint arm exoskeleton.Journal of neuroengineering and rehabilitation · 2021Article
- Virtual Reality in the Neurosciences: Current Practice and Future Directions.Frontiers in surgery · 2021Review
- A Flexible Pulse Generator Based on a Field Programmable Gate Array Architecture for Functional Electrical Stimulation.Frontiers in neuroscience · 2021Article
- Brain-Machine Neurofeedback: Robotics or Electrical Stimulation?Frontiers in bioengineering and biotechnology · 2020Article
- The Use of Functional Electrical Stimulation on the Upper Limb and Interscapular Muscles of Patients with Stroke for the Improvement of Reaching Movements: A Feasibility Study.Frontiers in neurology · 2017Article
- Combining Upper Limb Robotic Rehabilitation with Other Therapeutic Approaches after Stroke: Current Status, Rationale, and Challenges.BioMed research international · 2017Review
- Plasticity of premotor cortico-muscular coherence in severely impaired stroke patients with hand paralysis.NeuroImage. Clinical · 2017Article
- Proprioceptive Feedback Facilitates Motor Imagery-Related Operant Learning of Sensorimotor β-Band Modulation.Frontiers in neuroscience · 2017Article
- Hybrid Neuroprosthesis for the Upper Limb: Combining Brain-Controlled Neuromuscular Stimulation with a Multi-Joint Arm Exoskeleton.Frontiers in neuroscience · 2016Article
- Closed-Loop Task Difficulty Adaptation during Virtual Reality Reach-to-Grasp Training Assisted with an Exoskeleton for Stroke Rehabilitation.Frontiers in neuroscience · 2016Article
- Compensation or Restoration: Closed-Loop Feedback of Movement Quality for Assisted Reach-to-Grasp Exercises with a Multi-Joint Arm Exoskeleton.Frontiers in neuroscience · 2016Article
- What Turns Assistive into Restorative Brain-Machine Interfaces?Frontiers in neuroscience · 2016Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke patients with severe motor deficits cannot execute task-oriented rehabilitation exercises with their affected upper extremity. Advanced rehabilitation technology may support them in performing such reach-to-grasp movements. The challenge is, however, to provide assistance as needed, while maintaining the participants' commitment during the exercises. In this feasibility study, we introduced a closed-loop neuroprosthesis for reach-to-grasp assistance which combines adaptive multi-channel neuromuscular stimulation with a multi-joint arm exoskeleton. Eighteen severely affected chronic stroke patients were assisted by a gravity-compensating, seven-degree-of-freedom exoskeleton which was attached to the paretic arm for performing reach-to-grasp exercises resembling activities of daily living in a virtual environment. During the exercises, adaptive electrical stimulation was applied to seven different muscles of the upper extremity in a performance-dependent way to enhance the task-oriented movement trajectory. The stimulation intensity was individualized for each targeted muscle and remained subthreshold, i.e., induced no overt support. Closed-loop neuromuscular stimulation could be well integrated into the exoskeleton-based training, and increased the task-related range of motion (p = 0.0004) and movement velocity (p = 0.015), while preserving accuracy. The highest relative stimulation intensity was required to facilitate the grasping function. The facilitated range of motion correlated with the upper extremity Fugl-Meyer Assessment score of the patients (p = 0.028). Combining adaptive multi-channel neuromuscular stimulation with antigravity assistance amplifies the residual motor capabilities of severely affected stroke patients during rehabilitation exercises and may thus provide a customized training environment for patient-tailored support while preserving the participants' engagement.
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