ArticlePain research & management2016
Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite.
Article in Pain research & management, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
34 citing papers in PubMed.
- Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial.Nutrients · 2021Trial
- Pain mediates the association between psychological distress and increases in inflammation in middle-aged and older rural adults: A longitudinal cohort study.Brain, behavior, & immunity - health · 2026Article
- Real-Time and Long-Term Effects of Medical Marijuana on Older Adults: Protocol for a Prospective Cohort Study.JMIR research protocols · 2026Article
- A Systematic Review of Lifestyle Interventions for Neuropathy and Neuropathic Pain: Smoking Cessation.NeuroSci · 2025Review
- Using intensive longitudinal assessment to study mechanisms of the Native American pain inequity among persons experiencing depression and/or anxiety: The role of interpersonal discrimination and stress.The journal of pain · 2025Article
- More than chronic pain: behavioural and psychosocial protective factors predict lower brain age in adults with/at risk of knee osteoarthritis over two years.Brain communications · 2025Article
- Measurement of Pain Frequency Associated With Knee Osteoarthritis: Future Directions.The journal of pain · 2024Article
- NMDA Receptors Regulate Oxidative Damage in Keratinocytes during Complex Regional Pain Syndrome in HaCaT Cells and Male Rats.Antioxidants (Basel, Switzerland) · 2024Article
- Article
- Life course socioeconomic status, chronic pain, and the mediating role of allostatic load: findings from the midlife in the United States.Frontiers in public health · 2024Article
- Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes.Brain and behavior · 2023Article
- Elucidating individual differences in chronic pain and whole person health with allostatic load biomarkers.Brain, behavior, & immunity - health · 2023Article
- Conscious connected breathing with breath retention intervention in adults with chronic low back pain: protocol for a randomized controlled pilot study.Pilot and feasibility studies · 2023Article
- Consensus statement on smoking cessation in patients with pain.Journal of anesthesia · 2022Review
- Resveratrol Inhibition of the WNT/β-Catenin Pathway following Discogenic Low Back Pain.International journal of molecular sciences · 2022Article
- Chronic Pain Severity and Sociodemographics: An Evaluation of the Neurobiological Interface.The journal of pain · 2022Observational
- Associations between Vitamin D, Omega 6:Omega 3 Ratio, and Biomarkers of Aging in Individuals Living with and without Chronic Pain.Nutrients · 2022Article
- Combination of paeoniflorin and liquiritin alleviates neuropathic pain by lipid metabolism and calcium signaling coordination.Frontiers in pharmacology · 2022Article
- Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals.The journal of nutrition, health & aging · 2022Article
- Gut microbiota alterations may increase the risk of prescription opioid use, but not vice versa: A two-sample bi-directional Mendelian randomization study.Frontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Background. Chronic pain is associated with increased morbidity and mortality, predominated by cardiovascular disease and cancer. Investigating related risk factor measures may elucidate the biological burden of chronic pain. Objectives. We hypothesized that chronic pain severity would be positively associated with the risk factor composite. Methods. Data from 12,982 participants in the 6th Tromsø study were analyzed. Questionnaires included demographics, health behaviors, medical comorbidities, and chronic pain symptoms. The risk factor composite was comprised of body mass index, fibrinogen, C-reactive protein, and triglycerides. Chronic pain severity was characterized by frequency, intensity, time/duration, and total number of pain sites. Results. Individuals with chronic pain had a greater risk factor composite than individuals without chronic pain controlling for covariates and after excluding inflammation-related health conditions (p < 0.001). A significant "dose-response" relationship was demonstrated with pain severity (p < 0.001). In individuals with chronic pain, the risk factor composite varied by health behavior, exercise, lower levels and smoking, and higher levels. Discussion. The risk factor composite was higher in individuals with chronic pain, greater with increasing pain severity, and influenced by health behaviors. Conclusions. Identification of a biological composite sensitive to pain severity and adaptive/maladaptive behaviors would have significant clinical and research utility.
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