Evidence map›Paper›PMID 27445571›Full record

ArticleCanadian respiratory journal2016

Predictors of Poor Outcomes in Critically Ill Adults with Hematologic Malignancy.

Marion Cornish, Michael B Butler, Robert S Green

Registry-linked trialAbstract read
In one paragraph

Article in Canadian respiratory journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03449953 (Critical Care Outcomes of Patients With Hematologic Malignancy and Hematopoietic Cell Transplantation), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03449953 active not recruitingnot on this mapstarted 2018, after this paper: background citation

Critical Care Outcomes of Patients With Hematologic Malignancy and Hematopoietic Cell Transplantation

TypeobservationalSponsorMount Sinai Hospital, CanadaRan2018 to 2026Enrolled415ConditionsHematologic Malignancy, Stem Cell Transplant
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Failure of Noninvasive Ventilation in Acute Respiratory Failure is Associated with Higher Mortality in Patients with Solid Tumors: A Retrospective Cohort Study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marion CornishDepartment of Critical Care, Dalhousie University, Halifax, NS, Canada B3H 2Y9.
Michael B ButlerDepartment of Critical Care, Dalhousie University, Halifax, NS, Canada B3H 2Y9.
Robert S GreenDepartment of Critical Care, Dalhousie University, Halifax, NS, Canada B3H 2Y9; Trauma Nova Scotia, Halifax, NS, Canada B3H 2Y9.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. Patients with hematologic malignancy (HM) often require intensive care unit (ICU) admission due to organ failure through disease progression or treatment-related complications. Objective. To determine mortality and prognostic variables in adult patients with HM who were admitted to ICU. Methods. Structured chart review of all adult patients (age ≥ 18 years) with HM admitted to ICU of a Canadian tertiary care hospital between 2004 and 2014. Outcome measures included mortality (ICU, 30-day, 60-day, and 12-month). Logistic regression was performed to determine predictors of mortality. Results. Overall, there were 206 cases of HM admitted to the ICU during the study (mean age: 51.3 ± 13.6 years; 60% male). Median stay was 3 days, with 14.1% requiring prolonged ICU admission. ICU mortality was 45.6% and increased to 59.2% at 30 days, 62.6% at 60 days, and 74.3% at 12 months. Predictors of increased ICU mortality included mechanical ventilation requirement and vasopressor therapy requirement, while admission to ICU postoperatively and having myeloma were associated with decreased mortality. Conclusions. Patients admitted to ICU with HM have high mortality (45.6%), which increased to 74.3% at 1 year. Analysis of multiple variables identified critical illness, postsurgical admission, and myeloma as predictors of patient outcomes.

Indexed as

Hospital MortalityAdultAgedAge FactorsAnemiaCanadaCritical IllnessFebrile NeutropeniaFemaleGraft vs Host DiseaseHematologic NeoplasmsHumansIntensive Care UnitsLength of StayLeukemiaLogistic ModelsVasoconstrictor Agents

Identifiers

PMID27445571
PMCPMC4904527

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.