Evidence map›Paper›PMID 27445565›Full record

ArticleCanadian respiratory journal2016

A Step toward Tuberculosis Elimination in a Low-Incidence Country: Successful Diagnosis and Treatment of Latent Tuberculosis Infection in a Refugee Clinic.

Elissa Rennert-May, Elisabeth Hansen, Toktam Zadeh, Valerie Krinke, Stan Houston, Ryan Cooper

Abstract read
In one paragraph

Article in Canadian respiratory journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Treatment of tuberculosis infection among immigrants in southern New Brunswick, Canada: A cross-sectional study.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Tuberculosis Specific Interferon-Gamma Production in a Current Refugee Cohort in Western Europe.International journal of environmental research and public health · 2018
    Article
  12. Demographic predictors of active tuberculosis in people migrating to British Columbia, Canada: a retrospective cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018
    Article
  13. Prevalence of latent tuberculosis infection in Syrian refugees to Canada.Canadian journal of public health = Revue canadienne de sante publique · 2018
    Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elissa Rennert-MayInfectious Diseases, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2G3.
Elisabeth HansenEdmonton TB Clinic, Edmonton, AB, Canada T6G 2J3.
Toktam ZadehEdmonton TB Clinic, Edmonton, AB, Canada T6G 2J3.
Valerie KrinkeNew Canadians Clinic, Edmonton, AB, Canada T5M 3Z7.
Stan HoustonInfectious Diseases, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2G3; University of Alberta School of Public Health, Edmonton, AB, Canada T6G 1C9.
Ryan CooperInfectious Diseases, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2G3; Edmonton TB Clinic, Edmonton, AB, Canada T6G 2J3; University of Alberta School of Public Health, Edmonton, AB, Canada T6G 1C9.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives. Approximately 65 percent of tuberculosis (TB) cases in Canada each year occur from reactivation in foreign-born individuals. Refugees are at high risk after immigration. Routine screening of this population for latent TB infection (LTBI) is generally considered infeasible. We evaluated the outcome of LTBI screening and treatment amongst refugees. Methods. Government-sponsored refugees in Edmonton are seen at the New Canadians' Clinic and screened for TB and LTBI. We reviewed records of patients between 2009 and 2011. Completeness of initial assessment, diagnosis of latent infection, and completion of LTBI treatment were evaluated. Treatment for LTBI was offered when patients had a positive Tuberculin Skin Test (TST) and risk factors for progression to TB. An Interferon-Gamma Release Assay (IGRA) was performed on all other TST positives; treatment is only offered if it was positive. Results. 949 refugees were evaluated. 746 TSTs were read, with 265 positive individuals. IGRA testing was performed in 203 TST positive individuals without other TB risk factors; 110 were positive. LTBI treatment was offered to 147 of 151 eligible patients, 141 accepted, and 103 completed a treatment course. Conclusion. We observed high proportions of patient retention, completion of investigations, and treatment. This care model promises to be a component of effective TB prevention in this high-risk population.

Indexed as

RefugeesAdolescentAdultAlbertaAmbulatory CareAntitubercular AgentsCanadaChildDisease EradicationFemaleHumansInterferon-gamma Release TestsIsoniazidLatent TuberculosisMaleMass ScreeningAntitubercular AgentsIsoniazidRifampin

Identifiers

PMID27445565
PMCPMC4904499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.