ArticleCanadian respiratory journal2016
Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep Apnea.
Article in Canadian respiratory journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Effects of continuous positive airway pressure therapy on inflammatory markers in patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials.Sleep & breathing = Schlaf & Atmung · 2025Pooled it
- Peripheral blood oxidative stress markers for obstructive sleep apnea-a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2022Pooled it
- The effect of continuous positive airway pressure on circulating malondialdehyde among obstructive sleep apnea patients: a meta-analysis.Sleep & breathing = Schlaf & Atmung · 2020Pooled it
- Measurement of exhaled nitric oxide concentration in patients with obstructive sleep apnea: A meta-analysis.Medicine · 2017Pooled it
- Oxygen, carbon dioxide, and nitric oxide: role in the pathophysiology of obstructive sleep apnea.Medical gas research · 2027Review
- The Role of Mitochondria in Obstructive Sleep Apnea: Implications for the Upper Airway Muscles.International journal of molecular sciences · 2025Review
- Temporal Dynamics of Fractional Exhaled Nitric Oxide (FeNO) During CPAP Therapy in Obstructive Sleep Apnea: A Prospective Follow-Up Study.Nature and science of sleep · 2025Article
- Gut microbiota has important roles in the obstructive sleep apnea-induced inflammation and consequent neurocognitive impairment.Frontiers in microbiology · 2024Review
- Continuous positive airway pressure treatment of obstructive sleep apnea and hypertensive complications in high-risk pregnancy.Sleep & breathing = Schlaf & Atmung · 2023Article
- Circulating Malondialdehyde Concentrations in Obstructive Sleep Apnea (OSA): A Systematic Review and Meta-Analysis with Meta-Regression.Antioxidants (Basel, Switzerland) · 2021Review
- NOX4, MDA, IMA and oxidative DNA damage: can these parameters be used to estimate the presence and severity of OSA?Sleep & breathing = Schlaf & Atmung · 2021Article
- The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome.Journal of neuroinflammation · 2020Review
- Assessment of the relationship between polysomnography parameters and plasma malondialdehyde levels in patients with obstructive sleep apnea.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Article
- Article
- Inherent vs. Induced Loop Gain Abnormalities in Obstructive Sleep Apnea.Frontiers in neurology · 2018Review
- Estrogen Modulates the Sensitivity of Lung Vagal C Fibers in Female Rats Exposed to Intermittent Hypoxia.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Airway inflammation and oxidative stress may be linked in obstructive sleep apnea (OSA) patients. We determined the effectiveness of continuous positive airway pressure (CPAP) therapy in reducing fractional exhaled nitric oxide (FeNO) and malondialdehyde (MDA) levels in OSA patients. Methods. Thirteen patients with OSA and 13 normal controls were recruited. FeNO and MDA levels were measured in the controls and in OSA patients before and after three months of CPAP therapy. Results. FeNO and MDA levels were higher in the patients compared to the age and gender matched controls (FeNO: 25.9 ± 5.0 versus 17.5 ± 5.9 ppb, P < 0.001; MDA: 14.6 ± 7.8 versus 2.1 ± 0.3 μmol/L, P < 0.001). FeNO and MDA levels were lower post-CPAP compared to pre-CPAP (FeNO: 25.9 ± 5.0 versus 17.0 ± 2.3 ppb, P < 0.001; MDA: 14.6 ± 7.8 versus 10.0 ± 6.4 μmol/L, P < 0.01). Apnea-hypopnea index (15.9 ± 6.6 versus 4.1 ± 2.1/h, P < 0.001) and mean arterial pressure (P < 0.01) decreased following CPAP treatment. Daytime mean SpO2 (P < 0.05) increased. Conclusion. Our study demonstrates that CPAP therapy yields clinical benefits by reducing upper airway inflammation and oxidative stress in OSA patients.
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