ArticleJournal of applied physiology (Bethesda, Md. : 1985)2016
Dietary nitrate supplementation: impact on skeletal muscle vascular control in exercising rats with chronic heart failure.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Acute impact of inorganic nitrate supplementation after ischemia and during small muscle mass exercise in postmenopausal females: A pilot study.Physiological reports · 2024Trial
- Pharmacokinetics and Pharmacodynamics of Inorganic Nitrate in Heart Failure With Preserved Ejection Fraction.Circulation research · 2017Trial
- Influence of exercise training on nitric oxide pathways and their physiological effects.Redox biology · 2026Review
- Effect of pre-exercise dietary nitrate on skeletal muscle blood flow in a rat model of pulmonary hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Bulk and regional diaphragm blood flow during chemical hyperpnea in pulmonary hypertensive rats.Respiratory physiology & neurobiology · 2025Article
- Skeletal and respiratory muscle blood flow redistribution during submaximal exercise in pulmonary hypertensive rats.The Journal of physiology · 2025Article
- Capillary hemodynamics and contracting skeletal muscle oxygen pressures in male rats with heart failure: Impact of soluble guanylyl cyclase activator.Nitric oxide : biology and chemistry · 2022Article
- Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure.International journal of molecular sciences · 2021Review
- The role of vascular function on exercise capacity in health and disease.The Journal of physiology · 2021Review
- Vascular ATP-sensitive KThe Journal of physiology · 2020Article
- The effect of dietary nitrate supplementation on the speed-duration relationship in mice with sickle cell disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Article
- Transcapillary POThe Journal of physiology · 2020Article
- Does the Oral Microbiome Play a Role in Hypertensive Pregnancies?Frontiers in cellular and infection microbiology · 2020Review
- Edward F. Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- Central and peripheral factors mechanistically linked to exercise intolerance in heart failure with reduced ejection fraction.American journal of physiology. Heart and circulatory physiology · 2019Article
- Sexual dimorphism in the control of skeletal muscle interstitial PoJournal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Sex and nitric oxide bioavailability interact to modulate interstitial PoJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Effects of Dietary Inorganic Nitrate Supplementation on Exercise Performance in Patients With Heart Failure: Protocol for a Randomized, Placebo-Controlled, Cross-Over Trial.JMIR research protocols · 2018Article
- Exercise limitations in heart failure with reduced and preserved ejection fraction.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Dietary nitrate supplementation opposes the elevated diaphragm blood flow in chronic heart failure during submaximal exercise.Respiratory physiology & neurobiology · 2018Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Chronic heart failure (CHF) results in central and peripheral derangements that ultimately reduce skeletal muscle O2 delivery and impair exercise tolerance. Dietary nitrate (NO3 (-)) supplementation improves skeletal muscle vascular function and tolerance to exercise. We tested the hypothesis that NO3 (-) supplementation would elevate exercising skeletal muscle blood flow (BF) and vascular conductance (VC) in CHF rats. Myocardial infarction (MI) was induced (coronary artery ligation) in young adult male rats. After 21 days of recovery, rats randomly received 5 days of NO3 (-)-rich beetroot juice (CHF + BR, n = 10) or a placebo (CHF, n = 10). Mean arterial pressure (carotid artery catheter) and skeletal muscle BF (radiolabeled microspheres) were measured during treadmill exercise (20 m/min, 5% grade). CHF-induced dysfunction, as determined by myocardial infarction size (29 ± 3% and 33 ± 4% in CHF and CHF + BR, respectively) and left ventricular end-diastolic pressure (18 ± 2 and 18 ± 2 mmHg in CHF and CHF + BR, respectively), and exercising mean arterial pressure (131 ± 3 and 128 ± 4 mmHg in CHF and CHF + BR, respectively) were not different (P > 0.05) between groups. Total exercising hindlimb skeletal muscle BF (95 ± 5 and 116 ± 9 ml·min(-1)·100 g(-1) in CHF and CHF + BR, respectively) and VC (0.75 ± 0.05 and 0.90 ± 0.05 ml·min(-1)·100 g(-1)·mmHg(-1) in CHF and CHF + BR, respectively) were 22% and 20% greater in BR-supplemented rats, respectively (P < 0.05). During exercise, BF in 9 and VC in 10 hindlimb muscles and muscle portions were significantly greater in the CHF + BR group. These results provide strong evidence that dietary NO3 (-) supplementation improves skeletal muscle vascular function during exercise in rats with CHF and, thus, support the use of BR as a novel therapeutic modality for the treatment of CHF.
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