ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2016
Strong Evidence for Pattern Separation in Human Dentate Gyrus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 1 of them a synthesis that pooled it.
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Who cites it
145 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Unveiling the hippocampal subfield changes across the Alzheimer's disease continuum: a systematic review of neuroimaging studies.Brain imaging and behavior · 2025Pooled it
- Cardiorespiratory fitness, hippocampal subfield volumes, and mnemonic discrimination task performance in aging.Human brain mapping · 2021Trial
- The Strength of Target Representations Drives Mnemonic Discrimination: Evidence From Extended Delay and Hippocampal Damage.Hippocampus · 2026Article
- Temporal Interference Modulates Medial Temporal and Frontoparietal Activity During Mnemonic Discrimination: A High-Resolution Whole-Brain fMRI Investigation.Hippocampus · 2026Article
- Principal Components Analysis Relates Hippocampal Trisynaptic Circuit to Vividness of Visual Mental Imagery.Brain and behavior · 2026Article
- The human hippocampus can pattern separate memories by meaning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Stress drives the hippocampus to prioritize statistical prediction over episodic encoding.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Maraviroc attenuates inflammation-exacerbated cognitive and amyloid pathology in an early-stage Alzheimer's disease mouse model.Translational psychiatry · 2026Article
- Smartphone-based detection of subtle memory decline in prodromal Alzheimer's disease.NPJ digital medicine · 2026Article
- Effects of novelty and reward-based fear extinction on memory generalization.Behaviour research and therapy · 2026Article
- Functional MRI of the Human Hippocampus at 10.5T: Pushing the Boundaries of Spatial Resolution.bioRxiv : the preprint server for biology · 2026Article
- Selective Modulation of Evidence Accumulation by Hippocampal Theta Oscillations During Mnemonic Decision-Making.Human brain mapping · 2026Article
- Hippocampal patterns and associative memory: Distinct intracranial EEG temporal encoding patterns support memory.bioRxiv : the preprint server for biology · 2026Article
- The effects of hippocampal dentate gyrus lesions on categorical face perception.Attention, perception & psychophysics · 2026Article
- Biased synaptic activation of dentate granule cells by exercise reflects inputs from the lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2026Article
- A Single-Cell Perspective on Remapping Human Adult Neurogenesis and Its Clinical Implications.Biomolecules · 2026Review
- Representational differentiation and integration within the hippocampal circuit during naturalistic stimuli.Communications biology · 2026Article
- Sharpened Visual Memory Representations Are Reflected in Inferotemporal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dentate Gyrus activation during visual but not auditory pattern separation: an investigation of perceptual modality differences in young and old individuals using fMRI.Frontiers in psychiatry · 2026Article
- In Vivo Analysis of Medial Perforant Path-Evoked Excitation and Inhibition in Dentate Granule Cells.eNeuro · 2025Article
85 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe hippocampus is proposed to be critical in distinguishing between similar experiences by performing pattern separation computations that create orthogonalized representations for related episodes. Previous neuroimaging studies have provided indirect evidence that the dentate gyrus (DG) and CA3 hippocampal subregions support pattern separation by inferring the nature of underlying representations from the observation of novelty signals. Here, we use ultra-high-resolution fMRI at 7 T and multivariate pattern analysis to provide compelling evidence that the DG subregion specifically sustains representations of similar scenes that are less overlapping than in other hippocampal (e.g., CA3) and medial temporal lobe regions (e.g., entorhinal cortex). Further, we provide evidence that novelty signals within the DG are stimulus specific rather than generic in nature. Our study, in providing a mechanistic link between novelty signals and the underlying representations, constitutes the first demonstration that the human DG performs pattern separation. SIGNIFICANCE STATEMENT: A fundamental property of an episodic memory system is the ability to minimize interference between similar episodes. The dentate gyrus (DG) subregion of the hippocampus is widely viewed to realize this function through a computation referred to as pattern separation, which creates distinct nonoverlapping neural codes for individual events. Here, we leveraged 7 T fMRI to test the hypothesis that this region supports pattern separation. Our results demonstrate that the DG supports representations of similar scenes that are less overlapping than those in neighboring subregions. The current study therefore is the first to offer compelling evidence that the human DG supports pattern separation by obtaining critical empirical data at the representational level: the level where this computation is defined.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.