Observational studyNefrologia : publicacion oficial de la Sociedad Espanola Nefrologia
Diabetic kidney disease: Is there a non-albuminuric phenotype in type 2 diabetic patients?
Observational study in Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparison of Nonalbuminuric and Albuminuric Diabetic Kidney Disease Among Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2022Pooled it
- Pooled it
- Baseline and 4-year associations between prediabetes and kidney impairment: Insights from the ILERVAS cohort.Diabetes, obesity & metabolism · 2026Article
- Integration of digital physicalomics and dual-fluid metabolomics flux ratios reveals tubular secretory dysfunction in early diabetic kidney disease.Frontiers in endocrinology · 2026Article
- Determinants of estimated glomerular filtration rate in patients with type 2 diabetes mellitus: A cross-sectional study.Biomedical reports · 2025Article
- Non-albuminuric Diabetic Kidney Disease Phenotype: Beyond Albuminuria.TouchREVIEWS in endocrinology · 2022Review
- Letter Regarding "Moderating Effects in Randomized Trials-Interpreting theKidney international reports · 2022Article
- Re-understanding and focusing on normoalbuminuric diabetic kidney disease.Frontiers in endocrinology · 2022Review
- Update on pathogenesis and diagnosis flow of normoalbuminuric diabetes with renal insufficiency.European journal of medical research · 2021Review
- Article
- Neutrophil count as a reliable marker for diabetic kidney disease in autoimmune diabetes.BMC endocrine disorders · 2020Article
- Prevalence and awareness of chronic kidney disease among adult diabetic outpatients in Northeast Ethiopia.BMC nephrology · 2020Article
- Association of the IgGBMJ open diabetes research & care · 2020Article
- Evolving spectrum of diabetic nephropathy.World journal of diabetes · 2019Review
- The Global Epidemiology of Diabetes and Kidney Disease.Advances in chronic kidney disease · 2018Review
- Article
- Clinical Profile of Nonproteinuric Kidney Disease in Type 2 Diabetic Patients in India.Indian journal of nephrologyArticle
- Prevalence of normoalbuminuric chronic kidney disease among individuals with type 2 diabetes mellitus from India.The Indian journal of medical researchArticle
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlbuminuria was widely considered as the first clinical sign of diabetic kidney disease (DKD), which is why it has traditionally been used as a screening test for DKD. However, increasing evidence has shown that a significant number of type 2 diabetes mellitus (DM) patients have a decreased glomerular filtration rate (GFR) without significant albuminuria, known as non-albuminuric DKD (NA-DKD). The aim of this study was to determine the prevalence and the demographic and clinical characteristics of patients with NA-DKD.
methodsThis was a 1-year retrospective study that included 146 type 2 diabetic patients with GFR<75mL/min followed-up in a diabetes outpatient department. Patients were divided into two groups according to their ACR status - NA-DKD and albuminuric DKD (A-DKD).
resultsOf the 146 patients included in the study, 53.4% had A-DKD and 46.6% had NA-DKD. According to the multivariable analysis performed, patients with NA-DKD tended to be older (p=0.021), female (p=0.045) and with a lower GFR (p=0.004) than A-DKD patients. There was no difference between the groups in terms of body mass index, metabolic control of DM, duration of DM diagnosis and prevalence of metabolic syndrome.
conclusionsThe majority of patients with DKD had albuminuria, but a significant proportion had a non-albuminuric phenotype (46.6% in this population). These patients exhibit distinct clinical features that could have screening, therapeutic and prognosis implications.
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