Evidence map›Paper›PMID 27445060›Full record

ReviewPhysical therapy2017

Physical Training and Activity in People With Diabetic Peripheral Neuropathy: Paradigm Shift.

Patricia M Kluding, Sonja K Bareiss, Mary Hastings, Robin L Marcus, David R Sinacore, Michael J Mueller

3 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Physical therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 52 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 4 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04813133 nacompletednot on this mapstarted 2021, after this paper: background citation

Role of Synchronized Lifestyle Modification Program in Peripheral Neuropathy in Insulin Dependent Type 2 Diabetics

TypeinterventionalSponsorRiphah International UniversityRan2021 to 2022Enrolled216ConditionsDiabetic NeuropathiesArmsSynchronized Lifestyle Modification Program, Synchronized Lifestyle Modification Program and Physiotherapy, Physiotherapy
NCT04832464 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effects of BRACE (Balance, Resistance, Aerobic and Cognitive Exercise) Protocol for Balance Training in Patients With Diabetic Peripheral Neuropathy.

TypeinterventionalSponsorRiphah International UniversityRan2021 to 2022Enrolled60ConditionsDiabetic Peripheral Neuropathy (DPN)ArmsRACE Protocol: Balance training along with resistance, aerobic and cognitive exercises.
NCT06397209 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Comparative Effects of Propioceptive Neuromascular Facilitation and Neural Flossing on Balance and Gait in Diabetic Peripheral Neuropathy

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2024Enrolled50ConditionsDiabetic Peripheral NeuropathyArmsPropioceptive Neuromascular facilitation, Neural Flossing
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 4 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Patricia M Kluding
Sonja K Bareiss
Mary Hastings
Robin L Marcus
David R Sinacore
Michael J Mueller
Washington University in St. Louis · USEast Carolina University · USUniversity of Kansas Medical Center · USUniversity of Utah · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2M
NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

Diabetic peripheral neuropathy (DPN) occurs in more than 50% of people with diabetes and is an important risk factor for skin breakdown, amputation, and reduced physical mobility (ie, walking and stair climbing). Although many beneficial effects of exercise for people with diabetes have been well established, few studies have examined whether exercise provides comparable benefits to people with DPN. Until recently, DPN was considered to be a contraindication for walking or any weight-bearing exercise because of concerns about injuring a person's insensitive feet. These guidelines were recently adjusted, however, after research demonstrated that weight-bearing activities do not increase the risk of foot ulcers in people who have DPN but do not have severe foot deformity. Emerging research has revealed positive adaptations in response to overload stress in these people, including evidence for peripheral neuroplasticity in animal models and early clinical trials. This perspective article reviews the evidence for peripheral neuroplasticity in animal models and early clinical trials, as well as adaptations of the integumentary system and the musculoskeletal system in response to overload stress. These positive adaptations are proposed to promote improved function in people with DPN and to foster the paradigm shift to including weight-bearing exercise for people with DPN. This perspective article also provides specific assessment and treatment recommendations for this important, high-risk group.

Indexed as

Neuronal PlasticityPractice Guidelines as TopicDiabetic FootDiabetic NeuropathiesExerciseHumansMusculoskeletal DiseasesSkinSkin Physiological PhenomenaStress, PhysiologicalWeight-Bearing

Identifiers

PMID27445060
PMCPMC6256941
OpenAlexW2494489538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.