ArticleNeuroImage2016
T1 relaxometry of crossing fibres in the human brain.
Article in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest.PloS one · 2018Trial
- Fiber orientation-dependent TMagnetic resonance in medicine · 2025Article
- A Subtracted-Added-Divided Inversion Recovery (dSIR) Approach to Visualise the Effects of Microstructure on T1 Contrast in Human White Matter.NMR in biomedicine · 2025Article
- Mapping the aggregate g-ratio of white matter tracts using multi-modal MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- T1 relaxation and axon fibre configuration in human white matter.NMR in biomedicine · 2024Article
- A Comparison of White Matter Brain Differences in Monolingual and Highly Proficient Multilingual Speakers.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Alcohol use disorder: Neuroimaging evidence for accelerated aging of brain morphology and hypothesized contribution to age-related dementia.Alcohol (Fayetteville, N.Y.) · 2023Review
- Towards automated in vivo parcellation of the human cerebral cortex using supervised classification of magnetic resonance fingerprinting residuals.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- White matter microstructure and longitudinal relaxation time anisotropy in human brain at 3 and 7 T.NMR in biomedicine · 2023Article
- The human brain connectome weighted by the myelin content and total intra-axonal cross-sectional area of white matter tracts.Network neuroscience (Cambridge, Mass.) · 2023Article
- Combined diffusion-relaxometry microstructure imaging: Current status and future prospects.Magnetic resonance in medicine · 2021Review
- Measuring compartmental TNeuroImage · 2021Article
- Data-Driven multi-Contrast spectral microstructure imaging with InSpect: INtegrated SPECTral component estimation and mapping.Medical image analysis · 2021Article
- Hodology of the superior longitudinal system of the human brain: a historical perspective, the current controversies, and a proposal.Brain structure & function · 2021Review
- Toward nonparametric diffusion-Magnetic resonance in medicine · 2021Article
- Computing and visualising intra-voxel orientation-specific relaxation-diffusion features in the human brain.Human brain mapping · 2021Article
- The R1-weighted connectome: complementing brain networks with a myelin-sensitive measure.Network neuroscience (Cambridge, Mass.) · 2021Article
- Joint RElaxation-Diffusion Imaging Moments to Probe Neurite Microstructure.IEEE transactions on medical imaging · 2020Article
- A diffusion model-free framework with echo time dependence for free-water elimination and brain tissue microstructure characterization.Magnetic resonance in medicine · 2018Article
- Integrated and efficient diffusion-relaxometry using ZEBRA.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A comprehensive tract-based characterisation of white matter should include the ability to quantify myelin and axonal attributes irrespective of the complexity of fibre organisation within the voxel. Recently, a new experimental framework that combines inversion recovery and diffusion MRI, called inversion recovery diffusion tensor imaging (IR-DTI), was introduced and applied in an animal study. IR-DTI provides the ability to assign to each unique fibre population within a voxel a specific value of the longitudinal relaxation time, T1, which is a proxy for myelin content. Here, we apply the IR-DTI approach to the human brain in vivo on 7 healthy subjects for the first time. We demonstrate that the approach is able to measure differential tract properties in crossing fibre areas, reflecting the different myelination of tracts. We also show that tract-specific T1 has less inter-subject variability compared to conventional T1 in areas of crossing fibres, suggesting increased specificity to distinct fibre populations. Finally we show in simulations that changes in myelination selectively affecting one fibre bundle in crossing fibre areas can potentially be detected earlier using IR-DTI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.