Evidence map›Paper›PMID 27444553›Full record

ArticleBehavior genetics2016

A Test-Replicate Approach to Candidate Gene Research on Addiction and Externalizing Disorders: A Collaboration Across Five Longitudinal Studies.

Diana R Samek, Jennifer Bailey, Karl G Hill, Sylia Wilson, Susanne Lee, Margaret A Keyes, Marina Epstein, Andrew Smolen, Michael Miller, Ken C Winters and 4 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavior genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Reward Deficiency Syndrome (RDS): A Cytoarchitectural Common Neurobiological Trait of All Addictions.International journal of environmental research and public health · 2021
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Diana R SamekDepartment of Human Development and Family Studies, Auburn University, 203 Spidle Hall, Auburn, AL, 36849, USA. di.samek@gmail.com.
Jennifer BaileySchool of Social Work, University of Washington, Seattle, WA, USA.
Karl G HillSchool of Social Work, University of Washington, Seattle, WA, USA.
Sylia WilsonDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Susanne LeeDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
Margaret A KeyesDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Marina EpsteinSchool of Social Work, University of Washington, Seattle, WA, USA.
Andrew SmolenInstitute for Behavior Genetics, University of Colorado, Boulder, CO, USA.
Michael MillerDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Ken C WintersDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
J David HawkinsSchool of Social Work, University of Washington, Seattle, WA, USA.
Richard F CatalanoSchool of Social Work, University of Washington, Seattle, WA, USA.
William G IaconoDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.

Funding

REDUCING RISK &ENHANCING PROTECTIVE FACTORS IN CHILDRENR01DA008093 · NIDA · UNIVERSITY OF WASHINGTON · PI CATALANO, RICHARD F · 1993 to 2010
$12.4M
Substance Abuse & Behavioral Disinhibition: Integrating Genes & EnvironmentU01DA024417 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2007 to 2010
$10.8M
TWIN STUDY OF FEMALE ALCOHOLISMS AND OTHER DISORDERSR01AA009367 · NIAAA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 1992 to 2013
$9.0M
Gene-Environment Interplay in the Development of Drug Abuse, HIV Sexual Risk BehaR01DA024411 · NIDA · UNIVERSITY OF WASHINGTON · PI HILL, KARL GORDON · 2009 to 2015
$7.7M
Twin Family Study of Vulnerability to Substance AbuseR37DA005147 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2009 to 2018
$6.4M
SUBSTANCE USE AND TRANSITIONS TO ADULT ROLESR01DA009679 · NIDA · UNIVERSITY OF WASHINGTON · PI HAWKINS, J DAVID · 1996 to 2008
$6.1M
A Longitudinal Study of Adopted Youth and Their FamiliesR01MH066140 · NIMH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MCGUE, MATTHEW K. · 2003 to 2013
$5.8M
TWIN/FAMILY STUDY OF VULNERABILITY TO SUBSTANCE ABUSER01DA005147 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G · 1987 to 2007
$5.5M
Adolescent drinking and midlife outcomes: A prospective cotwin control studyR37AA009367 · NIAAA · UNIVERSITY OF MINNESOTA · PI MCGUE, MATTHEW K. · 2016 to 2024
$5.4M
TWIN STUDY OF ADHD, CD, AND SUBSTANCE ABUSER01DA013240 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI IACONO, WILLIAM G. · 2000 to 2010
$5.0M
YOUTH DRUG ABUSE, ADHD, AND RELATED DISRUPTIVE BEHAVIORSR01DA012995 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WINTERS, KEN C · 2000 to 2011
$3.6M
Adult consequences of youth substance use: Twin study enriched for SUD riskR01DA036216 · NIDA · UNIVERSITY OF MINNESOTA · PI IACONO, WILLIAM G. · 2013 to 2017
$3.2M
NIAAA NIH HHS R01 AA009367NIAAA NIH HHS R01 AA011886NIAAA NIH HHS R37 AA009367NIDA NIH HHS K01 DA037280NIDA NIH HHS R01 DA005147NIDA NIH HHS R01 DA008093NIDA NIH HHS R01 DA009679NIDA NIH HHS R01 DA012995NIDA NIH HHS R01 DA013240NIDA NIH HHS R01 DA024411NIDA NIH HHS R01 DA024417NIDA NIH HHS R01 DA036216NIDA NIH HHS R37 DA005147NIDA NIH HHS U01 DA024417NIMH NIH HHS R01 MH066140
6 · The paper itself

Abstract

This study presents results from a collaboration across five longitudinal studies seeking to test and replicate models of gene-environment interplay in the development of substance use and externalizing disorders (SUDs, EXT). We describe an overview of our conceptual models, plan for gene-environment interplay analyses, and present main effects results evaluating six candidate genes potentially relevant to SUDs and EXT (MAOA, 5-HTTLPR, COMT, DRD2, DAT1, and DRD4). All samples included rich longitudinal and phenotypic measurements from childhood/adolescence (ages 5-13) through early adulthood (ages 25-33); sample sizes ranged from 3487 in the test sample, to ~600-1000 in the replication samples. Phenotypes included lifetime symptom counts of SUDs (nicotine, alcohol and cannabis), adult antisocial behavior, and an aggregate externalizing disorder composite. Covariates included the first 10 ancestral principal components computed using all autosomal markers in subjects across the data sets, and age at the most recent assessment. Sex, ancestry, and exposure effects were thoroughly evaluated. After correcting for multiple testing, only one significant main effect was found in the test sample, but it was not replicated. Implications for subsequent gene-environment interplay analyses are discussed.

Indexed as

Cooperative BehaviorGenetic Association StudiesAdolescentBehavior, AddictiveChildFemaleGenealogy and HeraldryHumansLongitudinal StudiesMalePhenotypeReproducibility of ResultsSubstance-Related DisordersAddictionAlcoholCandidate gene studiesCannabisExternalizing disordersNicotineReplication studiesSubstance use disorders

Identifiers

PMID27444553
PMCPMC5060092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.