Evidence map›Paper›PMID 27444029›Full record

ArticleSurgery today2017

Protective effect of urapidil on testicular torsion-detorsion injury in rats.

Jakov Meštrović, Zenon Pogorelić, Irena Drmić-Hofman, Katarina Vilović, Davor Todorić, Marijana Popović

Abstract read
PubMed Publisher
In one paragraph

Article in Surgery today, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Samarcandin protects against testicular ischemia/reperfusion injury in rats via activation of Nrf2/HO-1-mediated antioxidant responses.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023
    Article
  3. Article
  4. Protective effect of osthole on testicular ischemia/reperfusion injury in rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022
    Article
  5. Article
  6. Article
  7. Antioxidant Potential of Parsley Leaf (BioMed research international · 2021
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jakov MeštrovićDepartment of Pediatric Surgery, Split University Hospital Centre and Split University School of Medicine, Spinčićeva 1, 21 000, Split, Croatia.
Zenon PogorelićDepartment of Pediatric Surgery, Split University Hospital Centre and Split University School of Medicine, Spinčićeva 1, 21 000, Split, Croatia. zpogorelic@gmail.com.
Irena Drmić-HofmanDepartment of Medical Chemistry and Biochemistry, University of Split School of Medicine, Spinčićeva 1, 21 000, Split, Croatia.
Katarina VilovićDepartment of Pathology, Forensic Medicine and Cytology, Split University Hospital Centre and Split University School of Medicine, Spinčićeva 1, 21 000, Split, Croatia.
Davor TodorićDepartment of Pediatric Surgery, Split University Hospital Centre and Split University School of Medicine, Spinčićeva 1, 21 000, Split, Croatia.
Marijana PopovićDepartment of Pathology, Forensic Medicine and Cytology, Split University Hospital Centre and Split University School of Medicine, Spinčićeva 1, 21 000, Split, Croatia.
Klinički Bolnički Centar Split · HRUniversity of Split · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to investigate the effect of urapidil and low-molecular weight heparin (LMWH) on testicular torsion-detorsion injury in rats.

methodsThirty-two male Sprague-Dawley rats were used. In the torsion-detorsion (T/D) group, the left testis was twisted at 720° for 3 h. After 3 h of reperfusion, the testis was removed. Urapidil or LMWH was administered intraperitoneally 30 min before detorsion in the treatment groups.

resultsUnilateral testicular torsion-detorsion caused significant increases in the malondialdehyde level and apoptosis and significant decreases in the superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in ipsilateral testes (p < 0.001). The rats treated with urapidil had a significant decrease in the malondialdehyde level and apoptosis and significant increases in the SOD and GPx activities in ipsilateral testes compared to the T/D group (p < 0.001). Animals treated with LMWH showed non-significant reductions in malondialdehyde levels and apoptosis compared to the T/D group. In addition, no significant difference in the SOD activities (p = 0.52) between the groups was found. The increase in the GPx activities was significant in the LMWH group compared to the T/D group (p < 0.001).

conclusionThe administration of urapidil before detorsion prevents ischemia/reperfusion cellular damage in testicular tissue. LMWH was not found to have a beneficial effect on testicular T/D injury in rats.

Indexed as

AnimalsApoptosisGlutathione PeroxidaseHeparin, Low-Molecular-WeightMaleMalondialdehydePiperazinesRats, Sprague-DawleyReperfusion InjurySpermatic Cord TorsionSuperoxide DismutaseTime FactorsGlutathione PeroxidaseHeparin, Low-Molecular-WeightMalondialdehydePiperazinesSuperoxide DismutaseurapidilApoptosisGlutathione peroxidaseIschemia–reperfusion damageLow-molecular weight heparinMalondialdehydeSuperoxide dismutaseTesticular torsionUrapidil

Identifiers

PMID27444029
OpenAlexW2484037831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.