ArticleScientific reports2016
The association between gallstones and metabolic syndrome in urban Han Chinese: a longitudinal cohort study.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Complex impacts of gallstone disease on metabolic syndrome and nonalcoholic fatty liver disease.Frontiers in endocrinology · 2022Pooled it
- Gallstone Disease and the Risk of Cardiovascular Disease.Scientific reports · 2019Pooled it
- Orlistat-Associated Gastrointestinal, Hepatobiliary, Pancreatic, and Anorectal Safety Signals: A FAERS Disproportionality and Regulatory Label Concordance Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Prevalence and metabolic correlates of gallbladder stones among community-dwelling older adults in Chongqing, China: a repeated cross-sectional study, 2018-2025.BMC gastroenterology · 2026Article
- Association between various insulin resistance surrogates and gallstone disease based on national health and nutrition examination survey.Scientific reports · 2025Article
- Association between fibrosis-4 index (FIB-4) and gallstones: an analysis of the NHANES 2017-2020 cross-sectional study.BMC gastroenterology · 2025Article
- Higher relative fat mass was associated with a higher prevalence of gallstones in US adults.BMC gastroenterology · 2025Article
- Impact of bile duct stenting on the management of symptomatic choledocholithiasis: a retrospective multicenter analysis.Frontiers in surgery · 2025Article
- Association between visceral lipid accumulation indicators and gallstones: a cross-sectional study based on NHANES 2017-2020.Lipids in health and disease · 2024Article
- Study on risk factors of impaired fasting glucose and development of a prediction model based on Extreme Gradient Boosting algorithm.Frontiers in endocrinology · 2024Article
- Phthalate and gallstones: the mediation of insulin.Frontiers in public health · 2024Article
- Associations between Life's Essential 8 and gallstones among US adults: A cross-sectional study from NHANES 2017-2018.PloS one · 2024Article
- Elevated metabolic score for visceral fat was associated with increased prevalence of gallstones in American adults: a cross-sectional study.Frontiers in medicine · 2024Article
- The association between triglyceride-glucose index and gallstones: NHANES 2017-2020.Frontiers in endocrinology · 2024Article
- The role of metabolic factors in the association between obesity and cholelithiasis: A two-step, two-sample multivariable mendelian randomization study.Clinics (Sao Paulo, Brazil) · 2024Article
- Different types and numbers metabolic abnormalities and risk of gallbladder stone disease in adults.Frontiers in nutrition · 2024Article
- Association between metabolically healthy overweight/obesity and gallstones in Chinese adults.Nutrition & metabolism · 2023Article
- Higher visceral adiposity index was associated with an elevated prevalence of gallstones and an earlier age at first gallstone surgery in US adults: the results are based on a cross-sectional study.Frontiers in endocrinology · 2023Article
- Causal association between metabolic syndrome and cholelithiasis: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- Higher levels of systemic immune-inflammatory index are associated with the prevalence of gallstones in people under 50 years of age in the United States: a cross-sectional analysis based on NHANES.Frontiers in medicine · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The precise association between metabolic syndrome (MetS) and gallstone disease remains unclear in China. This study aimed to clarify the relationship between MetS and gallstone and evaluate whether counts of metabolic abnormalities had influence on gallstone disease. We fitted gender-specific generalized estimating equation (GEE) regression models with data from a large-scale longitudinal study over 6-year follow-up to elucidate the real association. This study included 18291 participants with 3 times repeated measures at least who were free from a prior history of gallstone disease and cholecystectomy. A total of 873 cases of gallstones occurred during 6-year follow-up. The incidence density of gallstone in the group of subjects with MetS was higher than the group without MetS (10.27 vs 5.79). The GEE analyses confirmed and clarified the association between MetS and gallstone disease in males (RR = 1.33, P = 0.0020), while this association was not significant in females (RR = 1.15, P = 0.4962). With numbers of metabolic syndrome components increasing, the risk of gallstone disease showed corresponding increasing in males. In conclusion, the associations of MetS and gallstone are different in males and in females. And the risk of gallstone disease increases with the number of components of MetS for males but not for females.
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