ArticleEnvironmental geochemistry and health2017
Biological properties of mud extracts derived from various spa resorts.
Article in Environmental geochemistry and health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Modulation of Inflammatory and Redox Responses by Saturnia Spa Water and Mud Extract in Human Skin Cell Models.BioMed research international · 2026Article
- Exogenous Nucleotides Improve the Skin Aging of SAMP8 Mice by Modulating Autophagy through MAPKs and AMPK Pathways.Nutrients · 2024Article
- Microbial Polysaccharides Extracted from Different Mature Muds of the Euganean Thermal District Show Similar Anti-Inflammatory Activity In Vivo.International journal of molecular sciences · 2024Article
- The Effects of Lakitelek Thermal Water and Tap Water on Skin Microbiome, a Randomized Control Pilot Study.Life (Basel, Switzerland) · 2023Article
- Review
- Analysis of Massaciuccoli Peat after Maturation in Sodium Chloride Water of Undulna Thermae.International journal of environmental research and public health · 2022Article
- Microalgal Peloids for Cosmetic and Wellness Uses.Marine drugs · 2021Review
- Peloids as Thermotherapeutic Agents.International journal of environmental research and public health · 2021Article
- Fermented driedPharmaceutical biology · 2019Article
- The effects of humic water on endothelial cells under hyperglycemic conditions: inflammation-associated parameters.Environmental geochemistry and health · 2019Article
- Physicochemical characterization of sterilized muds for pharmaceutics/cosmetics applications.Environmental geochemistry and health · 2018Article
- The effect of topical 0.5% humic acid gel on male rats with skin ulcer.Journal of cutaneous and aesthetic surgeryArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spa resorts are known for thousands of years for their healing properties and have been empirically used for the treatment of many inflammatory conditions. Mud is one of the most often used natural materials for preventive, healing and cosmetic reasons and although it has been used since the antiquity, little light has been shed on its physical, chemical and biological properties. In this study we examined the effect of mud extracts on the expression of adhesion molecules (CAMs) by endothelial cells as well as their effects on monocyte adhesion to activated endothelial cells. Most of mud extracts inhibited the expression of VCAM-1 by endothelial cells and reduced monocyte adhesion to activated endothelial cells, indicating a potent anti-inflammatory activity. Furthermore, the mud extracts were tested for their antimicrobial activity; however, most of them appeared inactive against S. aureus and S. epidermidis. One of the mud extracts (showing the best stabilization features) increased significantly the expression of genes involved in cell protection, longevity and hydration of human keratinocytes, such as, collagen 6A1, forkhead box O3, sirtuin-1, superoxide dismutase 1 and aquaporin-3. The present study reveals that mud exerts important beneficial effects including anti-inflammatory and anti-aging activity as well as moisturizing effects, implicating important cosmeceutical applications.
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Registered trials
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