Evidence map›Paper›PMID 27443874›Full record

SynthesisJournal of orthopaedic surgery and research2016

Liposome bupivacaine for pain control after total knee arthroplasty: a meta-analysis.

Zhong Qing Wu, Ji Kang Min, Dan Wang, Yong Jian Yuan, Heng Li

2 registry-linked trialsOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of orthopaedic surgery and research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 6 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03859635 phase3completednot on this mapstarted 2019, after this paper: background citation

Randomized Prospective Study Comparing Exparel Erector Spinae Plane Block vs Simple Bupivacaine Erector Spinae Plane Block vs Exparel Surgeon Infiltration for Postoperative Analgesia Following Video-assisted Thoracoscopic Surgery

TypeinterventionalSponsorIndiana UniversityRan2019 to 2022Enrolled120ConditionsPain, Postoperative, Thoracic, Acute PainArmsLiposomal Bupivacaine, Bupivacaine, 0.25%, Bupivacaine, 0.5%
NCT04003987 phase3completednot on this mapstarted 2019, after this paper: background citation

Erector Spinae Plane Block Versus Transverse Abdominis Plane Block in Laparoscopic Hysterectomy

TypeinterventionalSponsorIndiana UniversityRan2019 to 2021Enrolled78ConditionsHysterectomyArmsLiposomal bupivacaine, bupivacaine, 0.125%
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Article
  8. Regional and Multimodal Analgesia to Reduce Opioid Use After Total Joint Arthroplasty: A Narrative Review.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhong Qing WuDepartment of Orthopedics, The First People's Hospital of Huzhou, 158 Guangchang hou road, Huzhou, Zhejiang Province, 313000, China.
Ji Kang MinDepartment of Orthopedics, The First People's Hospital of Huzhou, 158 Guangchang hou road, Huzhou, Zhejiang Province, 313000, China. minjikang007@sina.com.
Dan WangDepartment of Orthopedics, The First People's Hospital of Huzhou, 158 Guangchang hou road, Huzhou, Zhejiang Province, 313000, China.
Yong Jian YuanDepartment of Orthopedics, The First People's Hospital of Huzhou, 158 Guangchang hou road, Huzhou, Zhejiang Province, 313000, China.
Heng LiDepartment of Orthopedics, The First People's Hospital of Huzhou, 158 Guangchang hou road, Huzhou, Zhejiang Province, 313000, China.
Third People's Hospital of Huzhou · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTotal knee arthroplasty (TKA) is associated with intense and long-duration pain. Research is currently being conducted on the use of liposome bupivacaine (LB) to prolong the effects of local infiltration anesthesia. This systematic review and meta-analysis of randomized controlled trials (RCTs) evaluated the efficacy and safety of pain control of using LB versus placebo after TKA.

methodsIn April 2016, the Medline, Embase, PubMed, Cochrane Controlled Trials Register (CENTRAL), Web of Science, Google database, and Chinese Wanfang databases were searched to identify articles that compare a LB group versus a control group for pain control after TKA. This systematic review and meta-analysis were performed according to the PRISMA statement criteria. The primary endpoint was the visual analogue scale (VAS) score after TKA at 24, 48, and 72 h. The second outcome was nausea complications, which represent morphine-related side effects. Stata 12.0 software was used for the meta-analysis.

resultsFive studies involving 574 patients met the inclusion criteria. The meta-analysis revealed that LB can decrease the VAS score at 24 h (mean difference (MD) = -0.50; 95 % CI -0.97 to -0.04; P = 0.034), 48 h (MD = -0.26; 95 % CI -0.71 to 0.19; P = 0.256), and 72 h (MD = -0.26; 95 % CI -0.71 to 0.19; P = 0.256). There was no significant difference with respect to the length of hospital stay (MD = -0.08; 95 % CI -0.28 to 0.13; P = 0.475). Furthermore, LB can reduce the occurrence of nausea (RR = 0.38; 95 % CI 0.18 to 0.79; P = 0.009).

conclusionsBased on the current meta-analysis, LB as a novel anesthetic formulation administration following TKA demonstrated better pain control; however, the sample size was limited, and further RCTs are needed to identify the effects of LB after TKA.

Indexed as

Anesthetics, LocalArthroplasty, Replacement, KneeBupivacaineHumansLiposomesPain ManagementPostoperative PainRandomized Controlled Trials as TopicAnesthetics, LocalBupivacaineLiposomesLiposome bupivacaineMeta-analysisPain controlTotal knee arthroplasty

Identifiers

PMID27443874
PMCPMC4957351
OpenAlexW2495683184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.