ArticleGastroenterology2016
Clinical and Molecular Characteristics of Post-Colonoscopy Colorectal Cancer: A Population-based Study.
Article in Gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Clinical and Genomic Characterization of Interval Colorectal Cancer in 3 Prospective Cohorts.Gastroenterology · 2022Pooled it
- Integrative Proteogenomic Characterization of Left-Sided and Right-Sided Colorectal Cancer.MedComm · 2026Article
- Assessment of colorectal polyp detection along the short-axis direction of the intestinal lumen during colonoscopic observation: a retrospective study in Japan.Clinical endoscopy · 2026Article
- Incidence, characteristics, and predictive factors of post-colonoscopy colorectal cancer.United European gastroenterology journal · 2024Observational
- Clinicopathological and molecular differences between stage IV screen-detected and interval colorectal cancers in the Flemish screening program.Frontiers in oncology · 2024Article
- Open, Laparoscopic, and Robotic Approaches to Treat Colorectal Cancer: A Comprehensive Review of Literature.Cureus · 2023Review
- Mortality After Postcolonoscopy Colorectal Cancer in the Veterans Affairs Health Care System.JAMA network open · 2023Article
- Case report: POLE (P286R) mutation in a case of recurrent intestinal leakage and its treatment.Frontiers in oncology · 2023Article
- Characteristics of Interval Colorectal Cancer: A Canadian Retrospective Population-Level Analysis from Newfoundland and Labrador.Current oncology (Toronto, Ont.) · 2022Article
- Patient and Endoscopic Characteristics of Postcolonoscopy Colon Cancer-A Case-control Study.Gastro hep advances · 2022Article
- Risk of a post-colonoscopy colorectal cancer in patients with type 2 diabetes: a Danish population-based cohort study.BMJ open gastroenterology · 2021Article
- The Incidence, Distribution and Clinicopathology of Missed Colorectal Cancer After Diagnostic Colonoscopy.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Review
- Interval Colorectal Cancer 2006-2015: Novel Observations.Digestive diseases and sciences · 2021Article
- COVID-19: An Opportunity to Reimagine Colorectal Cancer Diagnostic Testing-A New Paradigm Shift.Clinical colorectal cancer · 2020Article
- Clinical Features and Genomic Characterization of Post-Colonoscopy Colorectal Cancer.Clinical and translational gastroenterology · 2020Article
- Development of a real-time endoscopic image diagnosis support system using deep learning technology in colonoscopy.Scientific reports · 2019Article
- Clinicopathologic and genetic characteristics of interval colorectal carcinomas favor origin from missed or incompletely excised precursors.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Article
- Recent advances in colorectal cancer screening.Chronic diseases and translational medicine · 2018Article
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10 authors at 6 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsColonoscopy provides incomplete protection from colorectal cancer (CRC), but determinants of post-colonoscopy CRC are not well understood. We compared clinical features and molecular characteristics of CRCs diagnosed at different time intervals after a previous colonoscopy.
methodsWe performed a population-based, cross-sectional study of incident CRC cases in Denmark (2007-2011), categorized as post-colonoscopy or detected during diagnostic colonoscopy (in patients with no prior colonoscopy). We compared prevalence of proximal location and DNA mismatch repair deficiency (dMMR) in CRC tumors, relative to time since previous colonoscopy, using logistic regression and cubic splines to assess temporal variation.
resultsOf 10,365 incident CRCs, 725 occurred after colonoscopy examinations (7.0%). These were more often located in the proximal colon (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.90-2.89) and were more likely to have dMMR (OR, 1.26; 95% CI, 1.00-1.59), but were less likely to be metastatic at presentation (OR, 0.65; 95% CI, 0.48-0.89) compared with CRCs diagnosed in patients with no prior colonoscopy. The highest proportions of proximal and/or dMMR tumors were observed in CRCs diagnosed 3-6 years after colonoscopy, but these features were still more frequent among cancers diagnosed up to 10 years after colonoscopy. The relative excess of dMMR tumors was most pronounced in distal cancers. In an analysis of 85 cases detected after colonoscopy, we found BRAF mutations in 23% of tumors and that 7% of cases had features of Lynch syndrome. Colonoscopy exams were incomplete in a higher proportion of cases diagnosed within <1 year (in 38%) than in those diagnosed within 1-10 years after colonoscopy (16%).
conclusionsIn a study of incident CRC cases in Denmark, we observed that tumors found in patients who have undergone colonoscopy are more often proximal and have dMMR compared to CRCs detected in patients without previous colonoscopies. The excess of right-sided tumors and the modest independent effects of dMMR reinforce the importance of proper colonoscopic examination of the proximal large bowel.
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