Evidence map›Paper›PMID 27443613›Full record

ArticleThe Journal of infectious diseases2016

Ebola Virus Shedding and Transmission: Review of Current Evidence.

Pauline Vetter, William A Fischer, Manuel Schibler, Michael Jacobs, Daniel G Bausch, Laurent Kaiser

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it, 163 citations in OpenAlex.

  1. Use of Ebola Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021
    Guideline
  2. Pooled it
  3. An imported case of Bundibugyo virus infection, France, June 2026.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026
    Article
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  16. Molecular determinants of cross-species transmission in emerging viral infections.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Pauline VetterDivision of Infectious Diseases, Geneva University Hospitals Laboratory of Virology and Swiss Reference Center for Emerging Viral Diseases.
William A FischerDivision of Pulmonary and Critical Care Medicine, University of North Carolina-Chapel Hill School of Medicine.
Manuel SchiblerDivision of Infectious Diseases, Geneva University Hospitals Laboratory of Virology and Swiss Reference Center for Emerging Viral Diseases University of Geneva Medical School, Switzerland.
Michael JacobsDepartment of Infectious Diseases, Royal Free London NHS Foundation Trust, United Kingdom.
Daniel G BauschTulane School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Laurent KaiserDivision of Infectious Diseases, Geneva University Hospitals Laboratory of Virology and Swiss Reference Center for Emerging Viral Diseases University of Geneva Medical School, Switzerland.
Geneva College · USRoyal Free London NHS Foundation Trust · GBTulane University · USUniversity of Geneva · CHUniversity of North Carolina at Chapel Hill · US

Funding

Clinical Sequelae and Urogenital Viral Dynamics in Survivors of Ebola Virus DiseaseR01AI123535 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISCHER, WILLIAM, WOHL, DAVID A · 2017 to 2021
$3.3M
Clinical Sequelae and Urogenital Viral Dynamics in Survivors of Ebola Virus DiseaseK23AI121516 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISCHER, WILLIAM · 2016 to 2019
$783k
The Effect of Aging on LAIV Replication in Human Nasal Epithelial CellsR03AG045088 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FISCHER, WILLIAM · 2013 to 2014
$152k
NIAID NIH HHS K23 AI121516NIAID NIH HHS R01 AI123535NIA NIH HHS R03 AG045088
6 · The paper itself

Abstract

backgroundThe magnitude of the 2013-2016 Ebola virus disease outbreak in West Africa was unprecedented, with >28 500 reported cases and >11 000 deaths. Understanding the key elements of Ebola virus transmission is necessary to implement adequate infection prevention and control measures to protect healthcare workers and halt transmission in the community.

methodsWe performed an extensive PubMed literature review encompassing the period from discovery of Ebola virus, in 1976, until 1 June 2016 to evaluate the evidence on modes of Ebola virus shedding and transmission.

findingsEbola virus has been isolated by cell culture from blood, saliva, urine, aqueous humor, semen, and breast milk from infected or convalescent patients. Ebola virus RNA has been noted in the following body fluids days or months after onset of illness: saliva (22 days), conjunctiva/tears (28 days), stool (29 days), vaginal fluid (33 days), sweat (44 days), urine (64 days), amniotic fluid (38 days), aqueous humor (101 days), cerebrospinal fluid (9 months), breast milk (16 months [preliminary data]), and semen (18 months). Nevertheless, the only documented cases of secondary transmission from recovered patients have been through sexual transmission. We did not find strong evidence supporting respiratory or fomite-associated transmission.

Indexed as

Disease OutbreaksVirus SheddingAfrica, WesternBodily SecretionsBody FluidsEbolavirusFecesFemaleHemorrhagic Fever, EbolaHumansMaleEbola virussheddingtransmission

Identifiers

PMID27443613
PMCPMC6283352
OpenAlexW2502757227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.