Evidence map›Paper›PMID 27443585›Full record

ReviewHead and neck pathology2017

Sinonasal Inflammatory Myofibroblastic Tumor with Anaplastic Lymphoma Kinase 1 Rearrangement: Case Study and Literature Review.

Ghizlene Lahlou, Marion Classe, Michel Wassef, Pierre-Alexandre Just, Nicolas Le Clerc, Philippe Herman, Benjamin Verillaud

Open access · bronzeAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Head and neck pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ghizlene LahlouENT Department, Lariboisiere Hospital, 2 Rue Ambroise Paré, 75010, Paris, France. ghizlene_lahlou@yahoo.fr.ORCID http://orcid.org/0000-0002-1067-045X
Marion ClassePathology Department, Lariboisiere Hospital, APHP, Paris 7 University, Paris, France.
Michel WassefPathology Department, Lariboisiere Hospital, APHP, Paris 7 University, Paris, France.
Pierre-Alexandre JustPathology Department, Cochin Hospital, APHP, Paris 5 University, Paris, France.
Nicolas Le ClercENT Department, Lariboisiere Hospital, 2 Rue Ambroise Paré, 75010, Paris, France.
Philippe HermanENT Department, Lariboisiere Hospital, 2 Rue Ambroise Paré, 75010, Paris, France.
Benjamin VerillaudENT Department, Lariboisiere Hospital, 2 Rue Ambroise Paré, 75010, Paris, France.
Université Paris Cité · FRHôpital Lariboisière · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory myofibroblastic tumors (IMTs) are rare mesenchymal tumors initially described in the lung. About half of them exhibit expression of the ALK1 protein, generally resulting from a gene rearrangement. Paranasal sinus IMTs are extremely uncommon, and gene rearrangement of ALK1 is very rare in this localization. A 47-year-old woman presented with rapidly progressive vision loss in her left eye. Clinical and imaging work-up revealed a tumor invading the left ethmoidal and sphenoidal sinuses and extending into the nasal cavity, the orbit and the skull base. Complete tumor resection was performed using an endonasal approach. Pathological examination revealed a paranasal localization of IMT, positive for ALK1 immunostaining. FISH analysis showed an ALK1 gene rearrangement. This case illustrates the local aggressive potential for IMTs. Treatment is primarily surgical, but targeted therapies (crizotinib) might be a solution for ALK1 rearranged cases with a poor prognosis.

Indexed as

Activin Receptors, Type IIFemaleGene RearrangementHumansMiddle AgedParanasal Sinus NeoplasmsSoft Tissue NeoplasmsActivin Receptors, Type IIACVRL1 protein, humanAnaplastic Lymphoma Kinase 1Endoscopic approachInflammatory myofibroblastic tumorSinonasal tumorTargeted therapies

Identifiers

PMID27443585
PMCPMC5429268
OpenAlexW2488375322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.