ArticleAnatolian journal of cardiology2017
Investigation of the effects of aging on the expression of aquaporin 1 and aquaporin 4 protein in heart tissue.
Article in Anatolian journal of cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- AQP1 differentially orchestrates endothelial cell senescence.Redox biology · 2024Article
- Identification of lncRNA-miRNA-mRNA Regulatory Network and Therapeutic Agents for Skin Aging by Bioinformatics Analysis.Biochemical genetics · 2023Article
- LncRNA-miRNA-mRNA regulatory networks in skin aging and therapeutic potentials.Frontiers in physiology · 2023Review
- AQP1 modulates tendon stem/progenitor cells senescence during tendon aging.Cell death & disease · 2020Article
- Investigating gene-microRNA networks in atrial fibrillation patients with mitral valve regurgitation.PloS one · 2020Article
- Aquaporin Channels in the Heart-Physiology and Pathophysiology.International journal of molecular sciences · 2019Review
- Effects of volatile anesthetic preconditioning on expression of NFkB-regulated genes in aged rat myocardium.Journal of biomedical research · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAquaporin (AQP) 1 and AQP 4 are expressed in human heart and several studies have been focused on these two aquaporins. For this purpose, the present study is aimed to research the effects of aging on AQP 1 and AQP 4 in heart tissue.
methodsIn this study, 14 Balb/C type white mice were used. Animals were divided into two equal groups. Group I consisted of 2-month-old young animals (n=7), and group II consisted of 18-month-old animals (n=7). To determine the AQP1 and AQP4 expression in the myocardium, the heart tissue was removed to perform western blotting and immunohistochemical and histopathological evaluations.
resultsMuscle fibers of the heart in aged animals were more irregular and loosely organized in hematoxylin-eosin (H-E) stained sections. Hscore analysis revealed that AQP1 and AQP4 immunoreactivity significantly increased in heart tissues of old mice compared with those of young mice (p<0.001). In addition, AQP1 and AQP4 protein expressions in the tissues of old animals were increased significantly according to western blot analysis (p=0.018 and p<0.001 for AQP1 and AQP4, respectively).
conclusionIncreased AQP1 and AQP4 levels in the heart tissue may be correlated with the maintenance of water and electrolytes balance, which decreases with aging. In this context, it might be the result of a compensatory response to decreased AQP4 functions. In addition, this increase with aging as demonstrated in our study might be one of the factors that increases the tendency of ischemia in elder people.
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