ArticleScientific reports2016
The Abiotic Chemistry of Thiolated Acetate Derivatives and the Origin of Life.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Harnessing PNature communications · 2026Article
- Thioesters Support Efficient Protein Biosynthesis by the Ribosome.ACS central science · 2025Article
- Prebiotic formation of thioesters via cyclic anhydrides as a key step in the emergence of metabolism.Scientific reports · 2025Article
- Rapid hydrolysis rates of thio- and phosphate esters constrain the origin of metabolism to cool, acidic to neutral environments.iScience · 2024Article
- Interaction between Cu and Thiols of Biological and Environmental Importance: Case Study Using Combined Spectrophotometric/Bathocuproine Sulfonate Disodium Salt Hydrate (BCS) Assay.Molecules (Basel, Switzerland) · 2023Article
- Thioesters provide a plausible prebiotic path to proto-peptides.Nature communications · 2022Article
- Thioester deprotection using a biomimetic NCL approach.Frontiers in chemistry · 2022Article
- Evolutionary Aspects of the Oxido-Reductive Network of Methylglyoxal.Journal of molecular evolution · 2021Article
- Decarbonylative Sulfide Synthesis from Carboxylic Acids and Thioesters via Cross-Over C-S Activation and Acyl Capture.Organic chemistry frontiers : an international journal of organic chemistry · 2021Article
- Thiols in the ISM: first detection of HC(O)SH and confirmation of CThe astrophysical journal. Letters · 2021Article
- Thioester synthesis through geoelectrochemical COCommunications chemistry · 2021Article
- Catalytic Hydrogenation of Thioesters, Thiocarbamates, and Thioamides.Journal of the American Chemical Society · 2020Article
- A way to thioacetate esters compatible with non-oxidative prebiotic conditions.Scientific reports · 2020Article
- Defining Lyfe in the Universe: From Three Privileged Functions to Four Pillars.Life (Basel, Switzerland) · 2020Article
- The Future of Origin of Life Research: Bridging Decades-Old Divisions.Life (Basel, Switzerland) · 2020Article
- Prebiotic Soup Components Trapped in Montmorillonite Nanoclay Form New Molecules: Car-Parrinello Ab Initio Simulations.Life (Basel, Switzerland) · 2019Article
- Chemistry of Homocysteine Thiolactone in A Prebiotic Perspective.Life (Basel, Switzerland) · 2019Article
- Native iron reduces CONature ecology & evolution · 2018Article
- Acetyl Phosphate as a Primordial Energy Currency at the Origin of Life.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
- Exploring chemoselective S-to-N acyl transfer reactions in synthesis and chemical biology.Nature communications · 2017Review
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thioesters and thioacetic acid (TAA) have been invoked as key reagents for the origin of life as activated forms of acetate analogous to acetyl-CoA. These species could have served as high-energy group-transfer reagents and allowed carbon insertions to form higher molecular weight compounds such as pyruvate. The apparent antiquity of the Wood-Ljungdahl CO2 fixation pathway and its presence in organisms which inhabit hydrothermal (HT) environments has also led to suggestions that there may be a connection between the abiotic chemistry of compounds similar to TAA and the origins of metabolism. These compounds' apparent chemical simplicity has made their prebiotic availability assumed, however, although the kinetic behavior and thermochemical properties of TAA and analogous esters have been preliminarily explored in other contexts, the geochemical relevance of these compounds merits further evaluation. Therefore, the chemical behavior of the simplest thiolated acetic acid derivatives, TAA and methylthioacetate (MTA) were explored here. Using laboratory measurements, literature data, and thermochemical models, we examine the plausibility of the accumulation of these compounds in various geological settings. Due to the high free energy change of their hydrolysis and corresponding low equilibrium constants, it is unlikely that these species could have accumulated abiotically to any significant extant.
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